Literature DB >> 25671791

A cell apoptosis probe based on fluorogen with aggregation induced emission characteristics.

Qinglian Hu1, Meng Gao, Guangxue Feng, Xiaodong Chen, Bin Liu.   

Abstract

A fluorogen-based aggregation-induced emission zinc-dipicolylamine (AIE-ZnDPA) probe with aggregation-induced emission characteristics has been designed and synthesized to detect cell apoptosis. AIE-ZnDPA does not respond to healthy cells but selectively stains and lights up fluorescence in the membranes of early stage apoptotic cells as well as the nuclei of late stage apoptotic cells. Without zinc coordination, the precursor lipophilic AIE dipicolylamine (AIE-DPA) probe stains healthy cells and shows high affinity for lipid droplets (LDs).

Entities:  

Keywords:  aggregation-induced emission; cell apoptosis; lipid droplet; zinc coordination

Mesh：

Substances：

Year:  2015        PMID： 25671791     DOI： 10.1021/am508838z

Source DB:  PubMed          Journal:  ACS Appl Mater Interfaces        ISSN： 1944-8244            Impact factor:   9.229


  7 in total

Review 1.  Imaging and therapeutic applications of zinc(ii)-dipicolylamine molecular probes for anionic biomembranes.

Authors:  Douglas R Rice; Kasey J Clear; Bradley D Smith
Journal:  Chem Commun (Camb)       Date:  2016-07-07       Impact factor: 6.222

2.  Time-lapse imaging of cell death in cell culture and whole living organisms using turn-on deep-red fluorescent probes.

Authors:  Tia S Jarvis; Felicia M Roland; Kyle M Dubiak; Paul W Huber; Bradley D Smith
Journal:  J Mater Chem B       Date:  2018-07-10       Impact factor: 6.331

3.  Phenoxide-Bridged Zinc(II)-Bis(dipicolylamine) Probes for Molecular Imaging of Cell Death.

Authors:  Kasey J Clear; Kara M Harmatys; Douglas R Rice; William R Wolter; Mark A Suckow; Yuzhen Wang; Mary Rusckowski; Bradley D Smith
Journal:  Bioconjug Chem       Date:  2015-09-11       Impact factor: 4.774

Review 4.  Aggregation-induced emission of siloles.

Authors:  Zujin Zhao; Bairong He; Ben Zhong Tang
Journal:  Chem Sci       Date:  2015-07-14       Impact factor: 9.825

5.  Efficient Bioimaging with Diaminodicyanoquinodimethanes: Selective Imaging of Epidermal and Stomatal Cells and Insight into the Molecular Level Interactions.

Authors:  N Senthilnathan; Ch G Chandaluri; T P Radhakrishnan
Journal:  Sci Rep       Date:  2017-09-06       Impact factor: 4.379

6.  Dual-Targeted Gold Nanoprism for Recognition of Early Apoptosis, Dual-Model Imaging and Precise Cancer Photothermal Therapy.

Authors:  Weiwei Zhang; Xiaoyuan Ding; Hao Cheng; Chenyang Yin; Jing Yan; Zhipeng Mou; Weiyun Wang; Danxi Cui; Cundong Fan; Dongdong Sun
Journal:  Theranostics       Date:  2019-07-28       Impact factor: 11.556

7.  Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles.

Authors:  Guorui Jin; Rongyan He; Qian Liu; Min Lin; Yuqing Dong; Kai Li; Ben Zhong Tang; Bin Liu; Feng Xu
Journal:  Theranostics       Date:  2019-01-01       Impact factor: 11.556
  7 in total

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