| Literature DB >> 25671691 |
Manuela Ariza1, Hartmuth C Kolb2, Dieder Moechars3, Frederik Rombouts1, José Ignacio Andrés4.
Abstract
Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most common cause of dementia among the elderly population. The good correlation of the density and neocortical spread of neurofibrillary tangles (NFTs) with clinical AD disease progression offers an opportunity for the early diagnosis and staging using a noninvasive imaging technique such as positron emission tomography (PET). Thus, PET imaging of NFTs not only holds promise as a diagnostic tool but also may enable the development of disease modifying therapeutics for AD. In this review, we focus on the structural diversity of tau PET tracers, the challenges related to the identification of high affinity and highly selective NFT ligands, and recent progress in the clinical development of tau PET radioligands.Entities:
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Year: 2015 PMID： 25671691 DOI： 10.1021/jm5017544
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446