| Literature DB >> 25670861 |
Ren-jie Wang1, Jian-wei Li2, Bu-he Bao1, Huan-cheng Wu2, Zhen-hua Du1, Jing-liang Su2, Ming-hua Zhang1, Hai-qian Liang3.
Abstract
Glioblastoma multiforme (GBM) is known as a highly malignant brain tumor with a poor prognosis, despite intensive research and clinical efforts. In this study, we observed that microRNA-873 (miR-873) was expressed at low levels in GBM and that the overexpression of miR-873 dramatically reduced the cell proliferation, migration, and invasion of GBM cells. Our further investigations of the inhibition mechanism indicated that miR-873 negatively affected the carcinogenesis and metastasis of GBM by down-regulating the expression of IGF2BP1, which stabilizes the mRNA transcripts of its target genes. These results demonstrate that miR-873 may constitute a potential target for GBM therapy.Entities:
Keywords: GBM; Gene Expression; Glioblastoma; IGF2BP1; Insulin-like Growth Factor (IGF); MicroRNA (miRNA); MicroRNA Mechanism; MicroRNA miR-873
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Year: 2015 PMID： 25670861 PMCID： PMC4423684 DOI： 10.1074/jbc.M114.624700
Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157