Takao Hamamoto1, Satoshi Fujii2, Masakazu Miyazaki3, Takeshi Shinozaki3, Toshifumi Tomioka3, Ryuichi Hayashi3. 1. Division of Head and Neck Surgery, National Cancer Center Hospital East, Chiba takao0320@hiroshima-u.ac.jp sfujii@east.ncc.go.jp. 2. Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan takao0320@hiroshima-u.ac.jp sfujii@east.ncc.go.jp. 3. Division of Head and Neck Surgery, National Cancer Center Hospital East, Chiba.
Abstract
OBJECTIVE: As neuroendocrine carcinomas in the head and neck region are extremely rare, their clinicopathological characteristics remain largely unknown. Moreover, the 2005 World Health Organization classification criteria for head and neck carcinomas with neuroendocrine features have numerous limitations. Therefore, the clinicopathological features and patient outcomes of these tumors must be clarified. METHODS: Between 2007 and 2012, we encountered nine cases of head and neck cancer involving a neuroendocrine carcinoma component. We investigated these tumors according to the 2010 World Health Organization classification criteria for neuroendocrine tumors, and their clinicopathological characteristics and clinical outcomes were examined. RESULTS: Carcinomas with neuroendocrine features were found to have an aggressive clinical course, which corresponded with the Ki-67 index and mitotic count. CONCLUSIONS: Owing to the difficulty in appropriately diagnosing head and neck carcinomas with neuroendocrine features using the current classification system, a new classification system should be developed for use in these cases.
OBJECTIVE: As neuroendocrine carcinomas in the head and neck region are extremely rare, their clinicopathological characteristics remain largely unknown. Moreover, the 2005 World Health Organization classification criteria for head and neck carcinomas with neuroendocrine features have numerous limitations. Therefore, the clinicopathological features and patient outcomes of these tumors must be clarified. METHODS: Between 2007 and 2012, we encountered nine cases of head and neck cancer involving a neuroendocrine carcinoma component. We investigated these tumors according to the 2010 World Health Organization classification criteria for neuroendocrine tumors, and their clinicopathological characteristics and clinical outcomes were examined. RESULTS:Carcinomas with neuroendocrine features were found to have an aggressive clinical course, which corresponded with the Ki-67 index and mitotic count. CONCLUSIONS: Owing to the difficulty in appropriately diagnosing head and neck carcinomas with neuroendocrine features using the current classification system, a new classification system should be developed for use in these cases.
Authors: Lauren Frenzel Schuch; Tuany Rafaeli Schmidt; Gisele de Oliveira Zigmundo; Laura Borges Kirschnick; Felipe Martins Silveira; Marco Antonio Trevizani Martins; Roman Carlos; Jean Nunes Dos Santos; Felipe Paiva Fonseca; Pablo Agustin Vargas; Vivian Petersen Wagner; Manoela Domingues Martins Journal: Head Neck Pathol Date: 2021-12-06