| Literature DB >> 25670209 |
H M Jones1, Y Chen, C Gibson, T Heimbach, N Parrott, S A Peters, J Snoeys, V V Upreti, M Zheng, S D Hall.
Abstract
The application of physiologically based pharmacokinetic (PBPK) modeling has developed rapidly within the pharmaceutical industry and is becoming an integral part of drug discovery and development. In this study, we provide a cross pharmaceutical industry position on "how PBPK modeling can be applied in industry" focusing on the strategies for application of PBPK at different stages, an associated perspective on the confidence and challenges, as well as guidance on interacting with regulatory agencies and internal best practices.Mesh：
Year: 2015 PMID： 25670209 DOI： 10.1002/cpt.37
Source DB: PubMed Journal: Clin Pharmacol Ther ISSN： 0009-9236 Impact factor: 6.875