Literature DB >> 25670036

Regulation of ABC transporters at the blood-brain barrier.

D S Miller1.   

Abstract

ATP binding cassette (ABC) transporters at the blood-brain barrier function as ATP-driven xenobiotic efflux pumps and limit delivery of small molecule drugs to the brain. Here I review recent progress in understanding the regulation of the expression and transport activity of these transporters and comment on how this new information might aid in improving drug delivery to the brain.
© 2014 American Society for Clinical Pharmacology and Therapeutics.

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Year:  2015        PMID： 25670036      PMCID： PMC4363166          DOI： 10.1002/cpt.64

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  70 in total

Review 1.  Functional expression and localization of P-glycoprotein at the blood brain barrier.

Authors:  Reina Bendayan; Gloria Lee; Moise Bendayan
Journal:  Microsc Res Tech       Date:  2002-06-01       Impact factor: 2.769

Review 2.  The blood-brain barrier in health and chronic neurodegenerative disorders.

Authors:  Berislav V Zlokovic
Journal:  Neuron       Date:  2008-01-24       Impact factor: 17.173

3.  Rapid loss of blood-brain barrier P-glycoprotein activity through transporter internalization demonstrated using a novel in situ proteolysis protection assay.

Authors:  Brian T Hawkins; Robert R Rigor; David S Miller
Journal:  J Cereb Blood Flow Metab       Date:  2010-07-14       Impact factor: 6.200

4.  In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation.

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Journal:  Mol Pharmacol       Date:  2006-07-12       Impact factor: 4.436

Review 5.  Do ATP-binding cassette transporters cause pharmacoresistance in epilepsy? Problems and approaches in determining which antiepileptic drugs are affected.

Authors:  Wolfgang Löscher; Carlos Luna-Tortós; Kerstin Römermann; Maren Fedrowitz
Journal:  Curr Pharm Des       Date:  2011       Impact factor: 3.116

6.  P-glycoprotein, breast cancer resistance protein, Organic Anion Transporter 3, and Transporting Peptide 1a4 during blood-brain barrier maturation: involvement of Wnt/β-catenin and endothelin-1 signaling.

Authors:  Rania Harati; Henri Benech; Anne Sophie Villégier; Aloïse Mabondzo
Journal:  Mol Pharm       Date:  2012-10-12       Impact factor: 4.939

Review 7.  ABC transporters in the CNS - an inventory.

Authors:  A M S Hartz; B Bauer
Journal:  Curr Pharm Biotechnol       Date:  2011-04       Impact factor: 2.837

8.  1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells.

Authors:  Matthew R Durk; Gary N Y Chan; Christopher R Campos; John C Peart; Edwin C Y Chow; Eason Lee; Ronald E Cannon; Reina Bendayan; David S Miller; K Sandy Pang
Journal:  J Neurochem       Date:  2012-11-01       Impact factor: 5.372

9.  Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier.

Authors:  Vishal S Narang; Charles Fraga; Narendra Kumar; Jun Shen; Stacy Throm; Clinton F Stewart; Christopher M Waters
Journal:  Am J Physiol Cell Physiol       Date:  2008-06-04       Impact factor: 4.249

10.  Nrf2 upregulates ATP binding cassette transporter expression and activity at the blood-brain and blood-spinal cord barriers.

Authors:  Xueqian Wang; Christopher R Campos; John C Peart; Lindsay K Smith; Jessica L Boni; Ronald E Cannon; David S Miller
Journal:  J Neurosci       Date:  2014-06-18       Impact factor: 6.167
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  29 in total

Review 1.  Blood-Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies.

Authors:  Loqman A Mohamed; Shashirekha Markandaiah; Silvia Bonanno; Piera Pasinelli; Davide Trotti
Journal:  AAPS J       Date:  2017-08-04       Impact factor: 4.009

2.  Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis.

Authors:  Hisham Qosa; Jessica Lichter; Mark Sarlo; Shashirekha S Markandaiah; Kevin McAvoy; Jean-Philippe Richard; Michael R Jablonski; Nicholas J Maragakis; Piera Pasinelli; Davide Trotti
Journal:  Glia       Date:  2016-05-09       Impact factor: 7.452

Review 3.  Disruption of small molecule transporter systems by Transporter-Interfering Chemicals (TICs).

Authors:  Sascha C T Nicklisch; Amro Hamdoun
Journal:  FEBS Lett       Date:  2020-12-09       Impact factor: 4.124

Review 4.  Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations.

Authors:  Yumi Yamamoto; Meindert Danhof; Elizabeth C M de Lange
Journal:  AAPS J       Date:  2017-03-09       Impact factor: 4.009

5.  Quantitative and Mechanistic Understanding of AZD1775 Penetration across Human Blood-Brain Barrier in Glioblastoma Patients Using an IVIVE-PBPK Modeling Approach.

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Journal:  Clin Cancer Res       Date:  2017-09-19       Impact factor: 12.531

Review 6.  Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders.

Authors:  Hisham Qosa; David S Miller; Piera Pasinelli; Davide Trotti
Journal:  Brain Res       Date:  2015-07-15       Impact factor: 3.252

7.  Structure and Function of the Blood-Brain Barrier (BBB).

Authors:  Fabienne Benz; Stefan Liebner
Journal:  Handb Exp Pharmacol       Date:  2022

8.  P-glycoprotein inhibition affects ivermectin-induced behavioural alterations in fed and fasted zebrafish (Danio rerio).

Authors:  Vinicius C Azevedo; Christopher J Kennedy
Journal:  Fish Physiol Biochem       Date:  2022-08-25       Impact factor: 3.014

9.  Basic physiology of the blood-brain barrier in health and disease: a brief overview.

Authors:  Mehmet Kaya; Bulent Ahishali
Journal:  Tissue Barriers       Date:  2020-11-15

10.  Protein Expression and Functional Relevance of Efflux and Uptake Drug Transporters at the Blood-Brain Barrier of Human Brain and Glioblastoma.

Authors:  Xun Bao; Jianmei Wu; Youming Xie; Seongho Kim; Sharon Michelhaugh; Jun Jiang; Sandeep Mittal; Nader Sanai; Jing Li
Journal:  Clin Pharmacol Ther       Date:  2019-12-10       Impact factor: 6.875
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