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Literature DB >> 2567003

Rapid increase in enzyme and peptide mRNA in sympathetic ganglia after electrical stimulation in humans.

M Schalling¹, P E Stieg, C Lindquist, M Goldstein, T Hökfelt.

Abstract

Thoracic ganglia in humans were studied after electrical, preganglionic stimulation using in situ hybridization with synthetic oligonucleotide probes against the catecholamine-synthesizing enzymes tyrosine hydroxylase (EC 1.14.16.2) and dopamine beta-hydroxylase (EC 1.14.17.1) and neuropeptide tyrosine. Immunohistochemical analysis was also performed. Following short peroperative stimulation a severalfold increase in all three mRNAs was found in principal ganglion cells, whereas no definite changes could be detected in enzyme or peptide levels with immunohistochemistry. The results suggest a very rapid and sensitive regulation of genes involved in signal transmission in the sympathetic nervous system of humans. Moreover, they indicate that electrical stimulation of neurons and/or pathways combined with in situ hybridization may be used as a method to define neuronal projections by visualizing increases in mRNAs for transmitter enzymes and/or peptide in target cells.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2567003 PMCID： PMC287440 DOI： 10.1073/pnas.86.11.4302

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

16 in total

1. MONOAMINES IN SYMPATHETIC GANGLIA STUDIED WITH FLUORESCENCE MICROSCOPY.

Authors: B HAMBERGER; K A NORBERG
Journal: Experientia Date: 1963-11-15

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Authors: H BLASCHKO
Journal: Br Med Bull Date: 1957-09 Impact factor: 4.291

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4. Coexistence and gene expression of phenylethanolamine N-methyltransferase, tyrosine hydroxylase, and neuropeptide tyrosine in the rat and bovine adrenal gland: effects of reserpine.

Authors: M Schalling; A Dagerlind; S Brené; H Hallman; M Djurfeldt; H Persson; L Terenius; M Goldstein; D Schlesinger; T Hökfelt
Journal: Proc Natl Acad Sci U S A Date: 1988-11 Impact factor: 11.205

5. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation.

Authors: S P Hunt; A Pini; G Evan
Journal: Nature Date: 1987 Aug 13-19 Impact factor: 49.962

6. Purification and characterization of tyrosine hydroxylase from a clonal pheochromocytoma cell line.

Authors: K A Markey; H Kondo; L Shenkman; M Goldstein
Journal: Mol Pharmacol Date: 1980-01 Impact factor: 4.436

7. A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics.

Authors: B Grima; A Lamouroux; C Boni; J F Julien; F Javoy-Agid; J Mallet
Journal: Nature Date: 1987 Apr 16-22 Impact factor: 49.962

8. Immunohistochemical localizatio of protein components of catecholamine storage vesicles.

Authors: L B Geffen; B G Livett; R A Rush
Journal: J Physiol Date: 1969-10 Impact factor: 5.182

9. Neuropeptide tyrosine in the rat adrenal gland--immunohistochemical and in situ hybridization studies.

Authors: M Schalling; K Seroogy; T Hökfelt; S Y Chai; H Hallman; H Persson; D Larhammar; A Ericsson; L Terenius; J Graffi
Journal: Neuroscience Date: 1988-01 Impact factor: 3.590

10. The primary structure of human dopamine-beta-hydroxylase: insights into the relationship between the soluble and the membrane-bound forms of the enzyme.

Authors: A Lamouroux; A Vigny; N Faucon Biguet; M C Darmon; R Franck; J P Henry; J Mallet
Journal: EMBO J Date: 1987-12-20 Impact factor: 11.598

7 in total

1. Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels.

Authors: Ming-Dong Zhang; Swapnali Barde; Ting Yang; Beilei Lei; Lars I Eriksson; Joseph P Mathew; Thomas Andreska; Katerina Akassoglou; Tibor Harkany; Tomas G M Hökfelt; Niccolò Terrando
Journal: Proc Natl Acad Sci U S A Date: 2016-10-10 Impact factor: 11.205

Rapid increase in enzyme and peptide mRNA in sympathetic ganglia after electrical stimulation in humans.

1. MONOAMINES IN SYMPATHETIC GANGLIA STUDIED WITH FLUORESCENCE MICROSCOPY.

2. Formation of catechol amines in the animal body.

3. Fluorescent antibody methods.

4. Coexistence and gene expression of phenylethanolamine N-methyltransferase, tyrosine hydroxylase, and neuropeptide tyrosine in the rat and bovine adrenal gland: effects of reserpine.

5. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation.

6. Purification and characterization of tyrosine hydroxylase from a clonal pheochromocytoma cell line.

7. A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics.

8. Immunohistochemical localizatio of protein components of catecholamine storage vesicles.

9. Neuropeptide tyrosine in the rat adrenal gland--immunohistochemical and in situ hybridization studies.

10. The primary structure of human dopamine-beta-hydroxylase: insights into the relationship between the soluble and the membrane-bound forms of the enzyme.

1. Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels.

2. Ultradian oscillations in somatostatin and growth hormone-releasing hormone mRNAs in the brains of adult male rats.

3. In situ hybridization study of neuropeptide Y neurons in the rat brain and pelvic paracervical ganglion.

4. Environmental modulations of the number of midbrain dopamine neurons in adult mice.

5. Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus.

6. Environmental and behavioral modulation of the number of substantia nigra dopamine neurons in adult mice.

Review 7. The diversity of neuronal phenotypes in rodent and human autonomic ganglia.