Literature DB >> 2566999

Structural features of the acetyl-CoA carboxylase gene: mechanisms for the generation of mRNAs with 5' end heterogeneity.

X C Luo1, K Park, F Lopez-Casillas, K H Kim.   

Abstract

Acetyl-CoA carboxylase [acetyl-CoA:carbondioxide ligase (ADP-forming), EC 6.4.1.2] is the rate-limiting enzyme in the biogenesis of long-chain fatty acids. We have previously characterized five acetyl-CoA carboxylase mRNA species that differ in their 5' untranslated regions but not in the coding region. We have now characterized the exon-intron structure of the genomic DNA that encodes the 5' untranslated region of the mRNA. Generation of different forms of the mRNA is the result of the selective use of two promoters and differential splicing of five different exons. These five exons contain a total of 645 nucleotides and they are scattered over a 50-kilobase-pair genomic DNA region that we have characterized.

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Year:  1989        PMID： 2566999      PMCID： PMC287384          DOI： 10.1073/pnas.86.11.4042

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

1.  Molecular cloning of cDNA for acetyl-coenzyme A carboxylase.

Authors:  D H Bai; M E Pape; F López-Casillas; X C Luo; J E Dixon; K H Kim
Journal:  J Biol Chem       Date:  1986-09-15       Impact factor: 5.157

2.  Structural organization of the mouse aspartate aminotransferase isoenzyme genes. Introns antedate the divergence of cytosolic and mitochondrial isoenzyme genes.

Authors:  K Obaru; T Tsuzuki; C Setoyama; K Shimada
Journal:  J Mol Biol       Date:  1988-03-05       Impact factor: 5.469

Review 3.  Regulation of acetyl-CoA carboxylase.

Authors:  K H Kim
Journal:  Curr Top Cell Regul       Date:  1983

Review 4.  Pre-mRNA splicing.

Authors:  M R Green
Journal:  Annu Rev Genet       Date:  1986       Impact factor: 16.830

5.  Identification of the promoter sequences involved in the cell specific expression of the rat somatostatin gene.

Authors:  O M Andrisani; T E Hayes; B Roos; J E Dixon
Journal:  Nucleic Acids Res       Date:  1987-07-24       Impact factor: 16.971

6.  Preparation of functional acetyl-CoA carboxylase mRNA from rat mammary gland.

Authors:  F López-Casillas; M E Pape; D H Bai; D N Kuhn; J E Dixon; K H Kim
Journal:  Arch Biochem Biophys       Date:  1987-08-15       Impact factor: 4.013

7.  A method for isolation of intact, translationally active ribonucleic acid.

Authors:  G Cathala; J F Savouret; B Mendez; B L West; M Karin; J A Martial; J D Baxter
Journal:  DNA       Date:  1983

8.  Alternative transcription and splicing of the human porphobilinogen deaminase gene result either in tissue-specific or in housekeeping expression.

Authors:  S Chretien; A Dubart; D Beaupain; N Raich; B Grandchamp; J Rosa; M Goossens; P H Romeo
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

9.  A rapid single-stranded cloning strategy for producing a sequential series of overlapping clones for use in DNA sequencing: application to sequencing the corn mitochondrial 18 S rDNA.

Authors:  R M Dale; B A McClure; J P Houchins
Journal:  Plasmid       Date:  1985-01       Impact factor: 3.466

10.  Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs.

Authors:  E A Leibold; H N Munro
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205
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  18 in total

1.  Different mRNAs code for dopa decarboxylase in tissues of neuronal and nonneuronal origin.

Authors:  M Krieger; F Coge; F Gros; J Thibault
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

2.  Complex pattern of alternative splicing generates unusual diversity in the leader sequence of the chicken link protein mRNA.

Authors:  F Deák; E Barta; S Mestric; M Biesold; I Kiss
Journal:  Nucleic Acids Res       Date:  1991-09-25       Impact factor: 16.971

3.  An enhancer element in the house-keeping promoter for acetyl-CoA carboxylase gene.

Authors:  X C Luo; K H Kim
Journal:  Nucleic Acids Res       Date:  1990-06-11       Impact factor: 16.971

Review 4.  An analysis of vertebrate mRNA sequences: intimations of translational control.

Authors:  M Kozak
Journal:  J Cell Biol       Date:  1991-11       Impact factor: 10.539

5.  The cyclic nucleotide phosphodiesterase gene of Dictyostelium discoideum contains three promoters specific for growth, aggregation, and late development.

Authors:  M Faure; J Franke; A L Hall; G J Podgorski; R H Kessin
Journal:  Mol Cell Biol       Date:  1990-05       Impact factor: 4.272

6.  Alterations in nutritional status regulate acetyl-CoA carboxylase expression in avian liver by a transcriptional mechanism.

Authors:  F B Hillgartner; T Charron; K A Chesnut
Journal:  Biochem J       Date:  1996-10-01       Impact factor: 3.857

7.  Characterization of a hepatoma mRNA transcribed from a third promoter of a 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-encoding gene and controlled by ets oncogene-related products.

Authors:  V J Dupriez; M I Darville; I V Antoine; A Gegonne; J Ghysdael; G G Rousseau
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-01       Impact factor: 11.205

8.  Inhibition of fatty acid synthesis by expression of an acetyl-CoA carboxylase-specific ribozyme gene.

Authors:  J Ha; K H Kim
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-11       Impact factor: 11.205

9.  Wheat acetyl-CoA carboxylase.

Authors:  P Gornicki; R Haselkorn
Journal:  Plant Mol Biol       Date:  1993-06       Impact factor: 4.076

10.  Induction of transcripts derived from promoter III of the acetyl-CoA carboxylase-alpha gene in mammary gland is associated with recruitment of SREBP-1 to a region of the proximal promoter defined by a DNase I hypersensitive site.

Authors:  Michael C Barber; Amanda J Vallance; Helen T Kennedy; Maureen T Travers
Journal:  Biochem J       Date:  2003-10-15       Impact factor: 3.857
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