Tatiana Falcone1, Damir Janigro2, Rachel Lovell3, Barry Simon4, Charles A Brown5, Mariela Herrera6, Aye Mu Myint7, Amit Anand8. 1. Cleveland Clinic, Neurologic Institute, Department of Neurology, 9500 Euclid Avenue, S60, Cleveland, OH 44195, USA; Cleveland Clinic, Neurologic Institute, Department of Psychiatry, 9500 Euclid Avenue, P57, Cleveland, OH 44195, USA. Electronic address: falcont1@ccf.org. 2. Cleveland Clinic, Lerner College of Medicine, Cerebrovascular Research NB-20 LRI, 9600 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: janigrd@ccf.org. 3. Begun Center for Violence Prevention Research and Education, Case Western Reserve University, 11402 Bellflower Road, Cleveland, OH 44106-7167, USA. Electronic address: Rachel.lovell@case.edu. 4. Cleveland Clinic, Department of Psychiatry, 9500 Euclid Avenue, P57, Cleveland, OH 44195, USA. Electronic address: simonb@ccf.org. 5. Cleveland Clinic, Department of Psychiatry, 9500 Euclid Avenue, P57, Cleveland, OH 44195, USA. Electronic address: brownc11@ccf.org. 6. Cleveland Clinic, Department of Psychiatry, 9500 Euclid Avenue, P57, Cleveland, OH 44195, USA. Electronic address: herrerm@ccf.org. 7. Laboratory for Psychoneuroimmunology, Psychiatric Hospital Ludwig-Maximilian University, Nussbaumstrasse, 780336 Munich, Germany. Electronic address: AyeMu.Mynt@med.uni-muenchen.de. 8. Cleveland Clinic, Department of Psychiatry, Center for Behavioral Health, 9500 Euclid Avenue P57, Cleveland, OH 44195, USA. Electronic address: ananda@ccf.org.
Abstract
BACKGROUND: Serum levels of the astrocytic protein S100B have been reported to indicate disruption of the blood-brain barrier. In this study, we investigated the relationship between S100B levels and childhood trauma in a child psychiatric inpatient unit. METHOD: Levels of S100B were measured in a group of youth with mood disorders or psychosis with and without history of childhood trauma as well as in healthy controls. Study participants were 93 inpatient adolescents admitted with a diagnosis of psychosis (N = 67), or mood disorder (N = 26) and 22 healthy adolescents with no history of trauma or psychiatric illness. Childhood trauma was documented using the Life Events Checklist (LEC) and Adverse Child Experiences (ACE). RESULTS: In a multivariate regression model, suicidality scores and trauma were the only two variables which were independently related to serum S100B levels. Patients with greater levels of childhood trauma had significantly higher S100B levels even after controlling for intensity of suicidal ideation. Patients with psychotic diagnoses and mood disorders did not significantly differ in their levels of S100B. Patients exposed to childhood trauma were significantly more likely to have elevated levels of S100B (p < .001) than patients without trauma, and patients with trauma had significantly higher S100B levels (p < .001) when compared to the control group. LEC (p = 0.046), and BPRS-C suicidality scores (p = 0.001) significantly predicted S100B levels. CONCLUSIONS: Childhood trauma can potentially affect the integrity of the blood-brain barrier as indicated by associated increased S100B levels.
BACKGROUND: Serum levels of the astrocytic protein S100B have been reported to indicate disruption of the blood-brain barrier. In this study, we investigated the relationship between S100B levels and childhood trauma in a childpsychiatric inpatient unit. METHOD: Levels of S100B were measured in a group of youth with mood disorders or psychosis with and without history of childhood trauma as well as in healthy controls. Study participants were 93 inpatient adolescents admitted with a diagnosis of psychosis (N = 67), or mood disorder (N = 26) and 22 healthy adolescents with no history of trauma or psychiatric illness. Childhood trauma was documented using the Life Events Checklist (LEC) and Adverse Child Experiences (ACE). RESULTS: In a multivariate regression model, suicidality scores and trauma were the only two variables which were independently related to serum S100B levels. Patients with greater levels of childhood trauma had significantly higher S100B levels even after controlling for intensity of suicidal ideation. Patients with psychotic diagnoses and mood disorders did not significantly differ in their levels of S100B. Patients exposed to childhood trauma were significantly more likely to have elevated levels of S100B (p < .001) than patients without trauma, and patients with trauma had significantly higher S100B levels (p < .001) when compared to the control group. LEC (p = 0.046), and BPRS-C suicidality scores (p = 0.001) significantly predicted S100B levels. CONCLUSIONS:Childhood trauma can potentially affect the integrity of the blood-brain barrier as indicated by associated increased S100B levels.
Authors: O Tomkins; D Kaufer; A Korn; I Shelef; H Golan; E Reichenthal; H Soreq; A Friedman Journal: Cell Mol Neurobiol Date: 2001-12 Impact factor: 5.046
Authors: M Kapural; Lj Krizanac-Bengez; G Barnett; J Perl; T Masaryk; D Apollo; P Rasmussen; M R Mayberg; D Janigro Journal: Brain Res Date: 2002-06-14 Impact factor: 3.252
Authors: Victoria M Sparrow-Downes; Sara Trincao-Batra; Paula Cloutier; Amanda R Helleman; Mina Salamatmanesh; William Gardner; Anton Baksh; Rishi Kapur; Nicole Sheridan; Sinthuja Suntharalingam; Lisa Currie; Liam D Carrie; Arthur Hamilton; Kathleen Pajer Journal: BMC Psychiatry Date: 2022-05-04 Impact factor: 3.630