Yi-Han Hsiao1,2, Yung-Tai Chen3,4, Ching-Min Tseng1,2,5, Li-An Wu6, Wei-Chen Lin7, Vincent Yi-Fong Su1,2, Diahn-Warng Perng2,8, Shi-Chuan Chang1,2,9, Yuh-Min Chen2,8, Tzeng-Ji Chen10,11, Yu-Chin Lee2,8, Kun-Ta Chou1,2,8,12. 1. Center of Sleep Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. 2. Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. 3. Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. 4. Department of Medicine, Taipei City Hospital Heping Fuyou Branch, Taipei, Taiwan. 5. Section of Respiratory Therapy, Department of Internal Medicine, Cheng Hsin General Hospital, Taipei, Taiwan. 6. Department of Radiology, Taipei City Hospital Heping Fuyou Branch, Taipei, Taiwan. 7. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan. 8. Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. 9. Institute of Emergency and Critical Care Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. 10. Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. 11. Institute of Hospital and Health Care Administration, School of Medicine, National Yang-Ming University, Taipei, Taiwan. 12. Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Abstract
STUDY OBJECTIVES: To explore the association between the non-apnea sleep disorder (NSD) and autoimmune diseases. DESIGN: Cohort study. SETTING: Nationwide database research. PARTICIPANTS: 84,996 adult patients with NSD diagnoses recorded in the Taiwan National Health Insurance Research Database between 2000 and 2003, after excluding those with antecedent autoimmune diseases. A comparison cohort of 84,996 participants was formed by age-, gender-, income-, and urbanization-matched controls. INTERVENTIONS: None. MEASUREMENTS AND RESULTS: The two cohorts were followed up for occurrence of autoimmune diseases, including rheumatoid arthritis (RA), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), and systemic sclerosis (SSc). A Cox proportional hazards regression model was used for muti-variate adjustment. In patients with NSD, the overall risk for incident autoimmune diseases was significantly higher than in controls (adjusted hazard ratio [HR] = 1.47, 95% confidence interval [CI] = 1.41-1.53). With regard to individual diseases, the risks for SLE, RA, AS and SS among NSD patients were also significantly higher than in controls (HR [95% CI] for SLE, RA, AS, and SS were 1.81 [1.50-2.18], 1.45 [1.36-1.54], 1.53 [1.38-1.70], and 1.51 [1.43-1.60], respectively), whereas the increased risk for SSc did not reach statistical significance (HR: 1.36 [0.82-2.26]). CONCLUSION: Patients with non-apnea sleep disorder were associated with a higher risk for developing autoimmune diseases.
STUDY OBJECTIVES: To explore the association between the non-apnea sleep disorder (NSD) and autoimmune diseases. DESIGN: Cohort study. SETTING: Nationwide database research. PARTICIPANTS: 84,996 adult patients with NSD diagnoses recorded in the Taiwan National Health Insurance Research Database between 2000 and 2003, after excluding those with antecedent autoimmune diseases. A comparison cohort of 84,996 participants was formed by age-, gender-, income-, and urbanization-matched controls. INTERVENTIONS: None. MEASUREMENTS AND RESULTS: The two cohorts were followed up for occurrence of autoimmune diseases, including rheumatoid arthritis (RA), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), and systemic sclerosis (SSc). A Cox proportional hazards regression model was used for muti-variate adjustment. In patients with NSD, the overall risk for incident autoimmune diseases was significantly higher than in controls (adjusted hazard ratio [HR] = 1.47, 95% confidence interval [CI] = 1.41-1.53). With regard to individual diseases, the risks for SLE, RA, AS and SS among NSDpatients were also significantly higher than in controls (HR [95% CI] for SLE, RA, AS, and SS were 1.81 [1.50-2.18], 1.45 [1.36-1.54], 1.53 [1.38-1.70], and 1.51 [1.43-1.60], respectively), whereas the increased risk for SSc did not reach statistical significance (HR: 1.36 [0.82-2.26]). CONCLUSION:Patients with non-apnea sleep disorder were associated with a higher risk for developing autoimmune diseases.
Authors: Janet M Mullington; Norah S Simpson; Hans K Meier-Ewert; Monika Haack Journal: Best Pract Res Clin Endocrinol Metab Date: 2010-10 Impact factor: 4.690
Authors: K A Young; M E Munroe; J B Harley; J M Guthridge; D L Kamen; G S Gilkensen; M H Weisman; D R Karp; D J Wallace; J A James; J M Norris Journal: Lupus Date: 2018-05-28 Impact factor: 2.858