Literature DB >> 2566918

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity.

A W Murray1, M J Solomon, M W Kirschner.   

Abstract

We show that cyclin plays a pivotal role in the control of mitosis. A proteolysis-resistant mutant of cyclin prevents the inactivation of maturation promoting factor and the exit from mitosis both in vivo and in vitro. We have used a fractionated extract to study the activation of MPF by added cyclin protein.

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Year:  1989        PMID： 2566918     DOI： 10.1038/339280a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  347 in total

1.  Influence of the G2 cell cycle block abrogator pentoxifylline on the expression and subcellular location of cyclin B1 and p34cdc2 in HeLa cervical carcinoma cells.

Authors:  T Theron; L Böhm
Journal:  Cell Prolif       Date:  2000-02       Impact factor: 6.831

2.  The yeast C-type cyclin Ctk2p is phosphorylated and rapidly degraded by the ubiquitin-proteasome pathway.

Authors:  G Hautbergue; V Goguel
Journal:  Mol Cell Biol       Date:  1999-04       Impact factor: 4.272

Review 3.  Cyclin/Cdk complexes: their involvement in cell cycle progression and mitotic division.

Authors:  P C John; M Mews; R Moore
Journal:  Protoplasma       Date:  2001       Impact factor: 3.356

4.  A complex degradation signal in Cyclin A required for G1 arrest, and a C-terminal region for mitosis.

Authors:  H W Jacobs; E Keidel; C F Lehner
Journal:  EMBO J       Date:  2001-05-15       Impact factor: 11.598

5.  Residual Cdc2 activity remaining at meiosis I exit is essential for meiotic M-M transition in Xenopus oocyte extracts.

Authors:  M Iwabuchi; K Ohsumi; T M Yamamoto; W Sawada; T Kishimoto
Journal:  EMBO J       Date:  2000-09-01       Impact factor: 11.598

6.  The degradation of two mitotic cyclins contributes to the timing of cytokinesis.

Authors:  Arnaud Echard; Patrick H O'Farrell
Journal:  Curr Biol       Date:  2003-03-04       Impact factor: 10.834

7.  A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts.

Authors:  G R Rosania; J Merlie; N Gray; Y T Chang; P G Schultz; R Heald
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-27       Impact factor: 11.205

Review 8.  Control of the G2/M transition.

Authors:  George R Stark; William R Taylor
Journal:  Mol Biotechnol       Date:  2006-03       Impact factor: 2.695

9.  Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.

Authors:  James R A Hutchins; Dina Dikovskaya; Paul R Clarke
Journal:  Mol Biol Cell       Date:  2003-07-11       Impact factor: 4.138

10.  Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest.

Authors:  F M Jault; J M Jault; F Ruchti; E A Fortunato; C Clark; J Corbeil; D D Richman; D H Spector
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103
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