| Literature DB >> 25668669 |
Jun Peng1, Li Chen, Zheng-Gang Zhu, Ze-Rong Zhu, Quan Hu, Yuan Fang.
Abstract
It has not been reported that administration of combining rabies vaccines and immunoglobulin resulted in acute disseminated encephalomyelitis (ADEM) yet. This report described that an old man acquired ADEM after being administrated with purified Vero cell rabies vaccine (PVRV) and Human Rabies Immunoglobulin (HRIG). Then he was given intravenous and oral glucocorticoids. Simultaneously, rabies vaccination was continued with purified Chick embryo cell vaccines (PCECV) instead of PVRV. Furthermore, we analyzed the rabies virus neutralizing antibodies (RVNA) levels in the patient's blood at different time points after rabies vaccination. Collectively, we observed that PCECV vaccination did not affect the prognosis of ADEM, and glucocorticoid was crucial and effective, which had no significant influence on efficacy of PCECV.Entities:
Keywords: ADEM; ADEM, acute disseminated encephalomyelitis; ANCA, Antineutrophil cytoplasmic antibodies; ASO, Anti-streptolycin O; CRP, C-reactive protein; CSF, Cerebrospinal fluid; CT, Computed tomography; EEG, electroencephalography; ESR, Erythrocyte sedimentation rate; FLAIR, fluid-attenuated inversion recovery; HDCV, human diploid cell vaccine; HRIG; HRIG, Human Rabies Immunoglobulin; MRI, magnetic resonance image; MS, multiple sclerosis; PCECV, purified Chick embryo cell vaccines; PEP, post-exposure prophylaxis; PPRC, Pharmacopoeia of the People's Republic of China; PVRV; PVRV, purified Vero cell rabies vaccine; RABV, rabies virus; RFFIT, rapid fluorescent focus inhibition test; RVNA; RVNA, rabies virus neutralizing antibodies; T2W, T2-weighted; glucocorticoids
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Year: 2014 PMID： 25668669 PMCID： PMC4514047 DOI： 10.4161/21645515.2014.979621
Source DB: PubMed Journal: Hum Vaccin Immunother ISSN： 2164-5515 Impact factor: 3.452