Michael Rönnlund1, Anna Sundström2, Rolf Adolfsson3, Lars-Göran Nilsson4. 1. Department of Psychology, Umeå University, Umeå, Sweden. Electronic address: michael.ronnlund@psy.umu.se. 2. Centre for Population Studies/Ageing and Living Conditions, Umeå University, Umeå, Sweden; Department of Psychology, Umeå University, Umeå, Sweden. 3. Division of Psychiatry, Department of Clinical Sciences, Umeå University, Umeå, Sweden. 4. Aging Research Center, Karolinska Institutet, Stockholm, Sweden; Umeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden.
Abstract
INTRODUCTION: The objective was to examine whether subjective memory impairment (SMI) predicts all-cause dementia or Alzheimer's disease (AD) in a population-based study with long-term follow-up (median = 10 years). METHODS: A total of 2043 initially dementia-free participants (≥ 60 years) made three memory ratings ("compared with others", "compared with five years ago", and "complaints from family/friends") at baseline. During follow-up, 372 participants developed dementia (208 with AD). RESULTS: Cox regression revealed that subjective memory impairment ratings predicted all-cause dementia in models adjusting for age and sex (hazard ratio or HR from 2.04 to 3.94), with even higher values for AD (HR from 2.29 to 5.74). The result persisted in models including other covariates, including baseline episodic memory performance, and in analyses restricted to participants with long time to dementia diagnosis (≥ 5 years). DISCUSSION: The findings underscore the usefulness of subjective memory assessment in combination with other factors in identifying individuals at risk for developing dementia.
INTRODUCTION: The objective was to examine whether subjective memory impairment (SMI) predicts all-cause dementia or Alzheimer's disease (AD) in a population-based study with long-term follow-up (median = 10 years). METHODS: A total of 2043 initially dementia-freeparticipants (≥ 60 years) made three memory ratings ("compared with others", "compared with five years ago", and "complaints from family/friends") at baseline. During follow-up, 372 participants developed dementia (208 with AD). RESULTS: Cox regression revealed that subjective memory impairment ratings predicted all-cause dementia in models adjusting for age and sex (hazard ratio or HR from 2.04 to 3.94), with even higher values for AD (HR from 2.29 to 5.74). The result persisted in models including other covariates, including baseline episodic memory performance, and in analyses restricted to participants with long time to dementia diagnosis (≥ 5 years). DISCUSSION: The findings underscore the usefulness of subjective memory assessment in combination with other factors in identifying individuals at risk for developing dementia.
Authors: Zoe Arvanitakis; Sue E Leurgans; Debra A Fleischman; Julie A Schneider; Kumar B Rajan; Jeremy J Pruzin; Raj C Shah; Denis A Evans; Lisa L Barnes; David A Bennett Journal: Ann Neurol Date: 2018-03-30 Impact factor: 10.422