Li-Han Hsu1, An-Chen Feng2, Shu-Huei Kao3, Chia-Chuan Liu4, Stella Y C Tsai5, Li-Sun Shih6, Nei-Min Chu7. 1. Division of Pulmonary and Critical Care Medicine, Sun Yat-Sen Cancer Center, Taipei, Taiwan, R.O.C. Department of Medicine, National Yang-Ming University Medical School, Taipei, Taiwan, R.O.C. lhhsu@kfsyscc.org. 2. Departments of Research, Sun Yat-Sen Cancer Center, Taipei, Taiwan, R.O.C. 3. School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, R.O.C. 4. Division of Thoracic Surgery, Sun Yat-Sen Cancer Center, Taipei, Taiwan, R.O.C. 5. Department of Radiation Oncology, Sun Yat-Sen Cancer Center, Taipei, Taiwan, R.O.C. 6. Department of Pathology, Sun Yat-Sen Cancer Center, Taipei, Taiwan, R.O.C. 7. Department of Medical Oncology, Sun Yat-Sen Cancer Center, Taipei, Taiwan, R.O.C.
Abstract
BACKGROUND/AIM: Estrogen is thought to play an important role in lung cancer carcinogenesis and progression. The incidence and survival of second primary lung cancer among breast cancer patients with and without anti-estrogen therapy were evaluated. PATIENTS AND METHODS: All women diagnosed with breast cancer and treated at the Sun Yat-Sen Cancer Center between January 2000 and December 2009 were included and followed-up for occurrence and/or death from lung cancer until December 2011. RESULTS: Twenty-six women developed second primary lung cancer among 6,361 breast cancer patients. All but one were adenocarcinoma and none had a smoking habit. Seventeen (65.4%) patients had previously received anti-estrogen treatment. The relative risk of developing second primary lung cancer among those who have received anti-estrogens for breast cancer and those who have not was 1.01 (95% confidence interval (CI)=0.45~2.28; p=0.970). Second primary lung cancer patients who have received anti-estrogens had a longer cancer-specific survival (p=0.007). The multivariate Cox proportional hazards analysis showed that anti-estrogen therapy remained an independent prognostic factor with a hazard ratio of 0.11 (95% CI=0.01~0.97, p=0.002) for second primary lung cancer patients. CONCLUSION: The results of this study further support the fact that estrogen adversely affects the prognosis of patients with lung cancer. However, the role of estrogen in lung cancer carcinogenesis remains to be determined. Copyright
BACKGROUND/AIM: Estrogen is thought to play an important role in lung cancer carcinogenesis and progression. The incidence and survival of second primary lung cancer among breast cancerpatients with and without anti-estrogen therapy were evaluated. PATIENTS AND METHODS: All women diagnosed with breast cancer and treated at the Sun Yat-Sen Cancer Center between January 2000 and December 2009 were included and followed-up for occurrence and/or death from lung cancer until December 2011. RESULTS: Twenty-six women developed second primary lung cancer among 6,361 breast cancerpatients. All but one were adenocarcinoma and none had a smoking habit. Seventeen (65.4%) patients had previously received anti-estrogen treatment. The relative risk of developing second primary lung cancer among those who have received anti-estrogens for breast cancer and those who have not was 1.01 (95% confidence interval (CI)=0.45~2.28; p=0.970). Second primary lung cancerpatients who have received anti-estrogens had a longer cancer-specific survival (p=0.007). The multivariate Cox proportional hazards analysis showed that anti-estrogen therapy remained an independent prognostic factor with a hazard ratio of 0.11 (95% CI=0.01~0.97, p=0.002) for second primary lung cancerpatients. CONCLUSION: The results of this study further support the fact that estrogen adversely affects the prognosis of patients with lung cancer. However, the role of estrogen in lung cancer carcinogenesis remains to be determined. Copyright
Authors: Tamar B Nobel; Rebecca A Carr; Raul Caso; Jennifer Livschitz; Samuel Nussenzweig; Meier Hsu; Kay See Tan; Smita Sihag; Prasad S Adusumilli; Matthew J Bott; Robert J Downey; James Huang; James M Isbell; Bernard J Park; Gaetano Rocco; Valerie W Rusch; David R Jones; Daniela Molena Journal: BJS Open Date: 2021-11-09