Atsushi Nanashima1, Hisayoshi Kondo2, Masahiro Nakashima3, Takafumi Abo4, Junichi Arai4, Mitsutoshi Ishii4, Shigekazu Hidaka4, Masaki Kunizaki4, Kazuo To4, Hiroaki Takeshita4, Naoya Yamasaki4, Tomoshi Tsuchiya4, Takeshi Nagayasu4. 1. Department of Surgical Oncology, Nagasaki University School of Biomedical Sciences, Nagasaki, Japan a-nanasm@nagasaki-u.ac.jp. 2. Biostatistic Section, Division of Scientific Data registry, Atomic Bomb Disease Institute, Nagasaki University School of Biomedical Sciences, Nagasaki, Japan. 3. Department of Tumor and Diagnostic Pathology in Atomic Bomb Disease Institute, Nagasaki University School of Biomedical Sciences, Nagasaki, Japan. 4. Department of Surgical Oncology, Nagasaki University School of Biomedical Sciences, Nagasaki, Japan.
Abstract
AIM: The present study was designed to define the clinicopathological characteristics of multiple cancers (MC) in 597 patients with hepatobiliary and pancreas (HBP) malignancies who underwent curative resection, in order to clarify risk factors and prognostic significance. PATIENTS AND METHODS: Patients' demographics, clinicopathological parameters and survival rates were compared between solitary (SC) and MC HBP malignancies for 267 patients with hepatocellular carcinoma (HCC), 77 with intrahepatic cholangiocarcinoma (ICC), 84 with extrahepatic bile duct carcinoma (BDC), 72 with gallbladder carcinoma (GBC) and 97 with pancreatic cancer (PC). RESULTS: MC was observed in 66 patients (11%) and more than three cancers were observed in 13 (2.2%). The mean age of patients of the MC group was significantly higher than that of the SC group. The proportion of Nagasaki atomic bomb survivors among the MC group was significantly higher than among the SC group. These findings were significant in HCC and ICC. The histopathological aggressiveness of malignancies was lower with HCC, BDC and PC. In HCC, the disease-free survival of MC patients with more than three tumors was significantly lower than those with SC and double cancers. In GBC, the overall survival of the MC group was significantly better than the SC group. In PC, the disease-free and overall survival were significantly better in MC than SC. CONCLUSION: Careful follow-up for second or third occurrence of primary malignancies after primary curative treatment for HBP malignancy is necessary. Copyright
AIM: The present study was designed to define the clinicopathological characteristics of multiple cancers (MC) in 597 patients with hepatobiliary and pancreas (HBP) malignancies who underwent curative resection, in order to clarify risk factors and prognostic significance. PATIENTS AND METHODS: Patients' demographics, clinicopathological parameters and survival rates were compared between solitary (SC) and MCHBP malignancies for 267 patients with hepatocellular carcinoma (HCC), 77 with intrahepatic cholangiocarcinoma (ICC), 84 with extrahepatic bile duct carcinoma (BDC), 72 with gallbladder carcinoma (GBC) and 97 with pancreatic cancer (PC). RESULTS:MC was observed in 66 patients (11%) and more than three cancers were observed in 13 (2.2%). The mean age of patients of the MC group was significantly higher than that of the SC group. The proportion of Nagasaki atomic bomb survivors among the MC group was significantly higher than among the SC group. These findings were significant in HCC and ICC. The histopathological aggressiveness of malignancies was lower with HCC, BDC and PC. In HCC, the disease-free survival of MCpatients with more than three tumors was significantly lower than those with SC and double cancers. In GBC, the overall survival of the MC group was significantly better than the SC group. In PC, the disease-free and overall survival were significantly better in MC than SC. CONCLUSION: Careful follow-up for second or third occurrence of primary malignancies after primary curative treatment for HBP malignancy is necessary. Copyright