Sebastian Szmit1, Joanna Streb2, Wioletta Starzec3, Dorota Zuziak4, Mariusz Kwiatkowski3, Bogumiła Czartoryska-Arłukowicz5, Dariusz Iżycki6, Anna Śmiałowska-Janiszewska7, Jerzy Hanslik8, Agnieszka Bryjak7, Małgorzata Talerczyk9, Jan Maciej Zaucha10. 1. Department of Pulmonary Circulation and Thromboembolic Diseases, Centre of Postgraduate Medical Education, Otwock, Poland s.szmit@gmail.com. 2. Department of Clinical Oncology, The University Hospital in Cracow, Cracow, Poland. 3. Department of Oncology, Franciszek Lukaszczyk Oncology Centre in Bydgoszcz, Bydgoszcz, Poland. 4. Department of Diagnosis and Treatment of Breast Cancer, Beskid Oncology Centre in Bielsko-Biała, Bielsko-Biała, Poland. 5. Department of Oncology, Medical University of Białystok, Białystok, Poland. 6. Department of Cancer Immunology, Poznan University of Medical Sciences, Poznań, Poland. 7. Chemotherapy Department, Regional Center of Oncology in Lodz, Łódź, Poland. 8. District Hospital Department of Chemotherapy in Racibórz, Racibórz, Poland. 9. West Pomeranian Oncology Center in Szczecin, Szczecin, Poland. 10. Department of Oncology and Propedeutic Oncology, Gdynia Oncology Center and Medical University of Gdansk, Gdynia, Poland.
Abstract
BACKGROUND: The knowledge of the epidemiology of left ventricular systolic dysfunction (LVSD) in relationship with cardiovascular diseases, their risk factors and history of previous anticancer therapy may lead to development of safer and more effective therapeutic strategies in patients with breast cancer (BC). PATIENTS AND METHODS: Oncologists from various Polish Centers reported 299 new cases of metastatic BC requiring chemotherapy. All registered previous cardiological and oncological therapies should be conducted in accordance with the mandatory guidelines. RESULTS: Twelve new cases (4%) of LVSD were recognized in echocardiography before current chemotherapy. Multivariate logistic regression analysis revealed a significant association of LVSD with hypercholesterolemia (odds ratio (OR)=8.83; 95% confidence interval (CI)=1.44-54.16; p<0.02), prior myocardial infarction (OR=26.81; 95%CI=2.26-318.43; p<0.01), prior antracycline-based therapy either neoadjuvant (OR=13.21; 95%CI=2.18-80.12, p=0.005) or adjuvant (OR=6.94; 95%CI=1.003-47.985, p<0.05). CONCLUSION: LVSD in metastatic BC reflects common negative effects of hypercholesterolemia, coronary events and neoadjuvant/adjuvant chemotherapy with anthracyclines. Copyright
BACKGROUND: The knowledge of the epidemiology of left ventricular systolic dysfunction (LVSD) in relationship with cardiovascular diseases, their risk factors and history of previous anticancer therapy may lead to development of safer and more effective therapeutic strategies in patients with breast cancer (BC). PATIENTS AND METHODS: Oncologists from various Polish Centers reported 299 new cases of metastatic BC requiring chemotherapy. All registered previous cardiological and oncological therapies should be conducted in accordance with the mandatory guidelines. RESULTS: Twelve new cases (4%) of LVSD were recognized in echocardiography before current chemotherapy. Multivariate logistic regression analysis revealed a significant association of LVSD with hypercholesterolemia (odds ratio (OR)=8.83; 95% confidence interval (CI)=1.44-54.16; p<0.02), prior myocardial infarction (OR=26.81; 95%CI=2.26-318.43; p<0.01), prior antracycline-based therapy either neoadjuvant (OR=13.21; 95%CI=2.18-80.12, p=0.005) or adjuvant (OR=6.94; 95%CI=1.003-47.985, p<0.05). CONCLUSION: LVSD in metastatic BC reflects common negative effects of hypercholesterolemia, coronary events and neoadjuvant/adjuvant chemotherapy with anthracyclines. Copyright
Authors: Marta Nowakowska; Edyta Płońska-Gościniak; Andrzej Szyszka; Łukasz Chrzanowski; Magdalena Krakowska; Piotr Potemski; Katarzyna Mizia-Stec; Zbigniew Gąsior; Artur Bodys; Maciej Siński; Adrianna Gościńska-Szmagała; Piotr Gościniak; Monika Różewicz; Beata Zaborska; Wojciech Braksator; Dariusz Kosior; Jarosław D Kasprzak Journal: Arch Med Sci Date: 2020-11-02 Impact factor: 3.318