Willem Den Otter1, Margot Hack2, John J L Jacobs3, Jurgen F V Tan4, Lawrence Rozendaal5, R Jeroen A Van Moorselaar3. 1. Department of Urology, VU Medical Centre, Amsterdam, the Netherlands w.denotter@VUmc.nl w.den.otter@live.nl. 2. Veterinary Centre Curacao, Ronde Klip, Curçao, the Netherlands. 3. Department of Urology, VU Medical Centre, Amsterdam, the Netherlands. 4. Veterinary Centre Korte Akkeren, Gouda, the Netherlands. 5. Department of Pathology, VU Medical Centre, Amsterdam, the Netherlands.
Abstract
AIM: To improve the treatment of transmissible venereal tumors (TVTs) in dogs with intratumoral injections of interleukin-2 (IL-2). PATIENTS AND METHODS: We treated 13 dogs with 18 natural TVTs with IL-2. The tumors were treated with intratumoral application of 2×10(6) units IL-2. RESULTS: Three months after injection of IL-2, the tumors in 2/13 dogs had regressed completely, those in 1/13 had regressed partially, and 4/13 dogs had stable disease. CONCLUSIONS: Local IL-2 treatment of TVT is therapeutically effective, as indicated by complete regression (CR), partial regression (PR) and stable disease (SD) of the tumors of 7 out of 13 dogs. In addition, we observed that the intratumoral treatment with IL-2 did not cause any toxic side-effects. Copyright
AIM: To improve the treatment of transmissible venereal tumors (TVTs) in dogs with intratumoral injections of interleukin-2 (IL-2). PATIENTS AND METHODS: We treated 13 dogs with 18 natural TVTs with IL-2. The tumors were treated with intratumoral application of 2×10(6) units IL-2. RESULTS: Three months after injection of IL-2, the tumors in 2/13 dogs had regressed completely, those in 1/13 had regressed partially, and 4/13 dogs had stable disease. CONCLUSIONS: Local IL-2 treatment of TVT is therapeutically effective, as indicated by complete regression (CR), partial regression (PR) and stable disease (SD) of the tumors of 7 out of 13 dogs. In addition, we observed that the intratumoral treatment with IL-2 did not cause any toxic side-effects. Copyright