Michelle Ang Co1, Luor Shyuan Maudrene Tan2, E Shyong Tai3, Konstadina Griva4, Mohamed Amir4, Kok Joon Chong1, Yung Seng Lee5, Jeannette Lee1, Eric Yin-Hao Khoo1, Hwee-Lin Wee6. 1. Department of Medicine, National University Health System, Singapore. 2. School of Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 3. Department of Medicine, National University Health System, Singapore; School of Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 4. Department of Psychology, National University of Singapore, Singapore. 5. Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 6. Department of Pharmacy, National University of Singapore, Singapore. Electronic address: phawhl@nus.edu.sg.
Abstract
BACKGROUND: Data on psychological distress (DIS), behavioral impact (BI) and health-related quality of life (HRQoL) are important yet lacking among Asian patients with Type 2 diabetes mellitus (T2DM). We aim to identify factors associated with DIS, BI and HRQoL among T2DM to better understand patient needs. METHODS: DIS was measured with Diabetes Health Profile (DHP-18) Psychological Distress (DHP-PD) subscale, Problem Areas in Diabetes (PAID) and Kessler-10 (K10), BI with DHP-18 Barriers to Activity and Disinhibited Eating subscales and HRQoL with Audit of Diabetes-Dependent Quality of Life. Multiple linear regression analyses were performed to evaluate the associations between these outcomes and patient demographic, socioeconomic status, glycated hemoglobin (HbA1C) and comorbidities. RESULTS: 213 T2DM patients (mean (SD) age: 45.0 (12.1) years, mean (SD) HbA1C: 8.3% (1.9%) and 70.0% reported at least one comorbidity) were evaluated. Poorer glycemic control was significantly associated with higher DHP-PD, PAID and worse HRQoL. Taking oral hypoglycemic agents plus insulin was independently associated with Barrier to Activity and Disinhibited Eating. CONCLUSION: Poorer glycemic control was only associated with diabetes-related distress (measured by DHP-PD and PAID) but not major depressive disorder (measured by K10). It may be more appropriate to screen for diabetes-related distress rather than major depressive disorder for patients with T2DM.
BACKGROUND: Data on psychological distress (DIS), behavioral impact (BI) and health-related quality of life (HRQoL) are important yet lacking among Asian patients with Type 2 diabetes mellitus (T2DM). We aim to identify factors associated with DIS, BI and HRQoL among T2DM to better understand patient needs. METHODS: DIS was measured with Diabetes Health Profile (DHP-18) Psychological Distress (DHP-PD) subscale, Problem Areas in Diabetes (PAID) and Kessler-10 (K10), BI with DHP-18 Barriers to Activity and Disinhibited Eating subscales and HRQoL with Audit of Diabetes-Dependent Quality of Life. Multiple linear regression analyses were performed to evaluate the associations between these outcomes and patient demographic, socioeconomic status, glycated hemoglobin (HbA1C) and comorbidities. RESULTS: 213 T2DM patients (mean (SD) age: 45.0 (12.1) years, mean (SD) HbA1C: 8.3% (1.9%) and 70.0% reported at least one comorbidity) were evaluated. Poorer glycemic control was significantly associated with higher DHP-PD, PAID and worse HRQoL. Taking oral hypoglycemic agents plus insulin was independently associated with Barrier to Activity and Disinhibited Eating. CONCLUSION: Poorer glycemic control was only associated with diabetes-related distress (measured by DHP-PD and PAID) but not major depressive disorder (measured by K10). It may be more appropriate to screen for diabetes-related distress rather than major depressive disorder for patients with T2DM.
Authors: Zheng Kang Lum; Melanie Yee Lee Siaw; Michelle Jia Xin Lee; Zexuan Koh; Parry Quan Zhang; Soo Kiang Eng; Swee Chin Tan; Joyce Yu-Chia Lee Journal: Qual Life Res Date: 2019-07-29 Impact factor: 4.147
Authors: Maudrene L Tan; Chuen S Tan; Konstadina Griva; Yung S Lee; Jeannette Lee; E S Tai; Eric Y Khoo; Hwee-Lin Wee Journal: BMC Endocr Disord Date: 2017-06-23 Impact factor: 2.763
Authors: Jessie N Zurita-Cruz; Leticia Manuel-Apolinar; María Luisa Arellano-Flores; Alejandro Gutierrez-Gonzalez; Alma Gloria Najera-Ahumada; Nelly Cisneros-González Journal: Health Qual Life Outcomes Date: 2018-05-15 Impact factor: 3.186