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Literature DB >> 25666945

Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease.

Abstract

Dicarbonyl stress is the abnormal accumulation of dicarbonyl metabolites leading to increased protein and DNA modification contributing to cell and tissue dysfunction in ageing and disease. Enzymes metabolising dicarbonyls, glyoxalase 1 and aldoketo reductases, provide an efficient and stress-response enzyme defence against dicarbonyl stress. Dicarbonyl stress is produced by increased formation and/or decreased metabolism of dicarbonyl metabolites, and by exposure to exogenous dicarbonyls. It contributes to ageing, disease and activity of cytototoxic chemotherapeutic agents.

Entities: Chemical

Keywords: Cardiovascular disease; Diabetes; Glycation; Hypoxia; Inflammation; Oxidative stress

Mesh：

Substances：

Year: 2015 PMID： 25666945 DOI： 10.1016/j.bbrc.2015.01.140

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

96 in total

Review 1. RAGE and glyoxalase in kidney disease.

Authors: Reiko Inagi
Journal: Glycoconj J Date: 2016-06-06 Impact factor: 2.916

2. A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification.

Authors: Jyotiska Chaudhuri; Neelanjan Bose; Jianke Gong; David Hall; Alexander Rifkind; Dipa Bhaumik; T Harshani Peiris; Manish Chamoli; Catherine H Le; Jianfeng Liu; Gordon J Lithgow; Arvind Ramanathan; X Z Shawn Xu; Pankaj Kapahi
Journal: Curr Biol Date: 2016-10-20 Impact factor: 10.834

3. Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration.

Authors: Sheldon Rowan; Shuhong Jiang; Tal Korem; Jedrzej Szymanski; Min-Lee Chang; Jason Szelog; Christa Cassalman; Kalavathi Dasuri; Christina McGuire; Ryoji Nagai; Xue-Liang Du; Michael Brownlee; Naila Rabbani; Paul J Thornalley; James D Baleja; Amy A Deik; Kerry A Pierce; Justin M Scott; Clary B Clish; Donald E Smith; Adina Weinberger; Tali Avnit-Sagi; Maya Lotan-Pompan; Eran Segal; Allen Taylor
Journal: Proc Natl Acad Sci U S A Date: 2017-05-15 Impact factor: 11.205

4. Ferulic acid prevents methylglyoxal-induced protein glycation, DNA damage, and apoptosis in pancreatic β-cells.

Authors: Weerachat Sompong; Henrique Cheng; Sirichai Adisakwattana
Journal: J Physiol Biochem Date: 2016-11-07 Impact factor: 4.158

Review 5. Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases.

Authors: Alejandro Gugliucci
Journal: Adv Nutr Date: 2017-01-17 Impact factor: 8.701

Review 6. Diabetes Mellitus as a Risk Factor for Parkinson's Disease: a Molecular Point of View.

Authors: Alice Biosa; Tiago F Outeiro; Luigi Bubacco; Marco Bisaglia
Journal: Mol Neurobiol Date: 2018-03-28 Impact factor: 5.590

7. Nitration and Glycation Turn Mature NGF into a Toxic Factor for Motor Neurons: A Role for p75^NTR and RAGE Signaling in ALS.

Authors: Mi Jin Kim; Marcelo R Vargas; Benjamin A Harlan; Kelby M Killoy; Lauren E Ball; Susana Comte-Walters; Monika Gooz; Yasuhiko Yamamoto; Joseph S Beckman; Luis Barbeito; Mariana Pehar
Journal: Antioxid Redox Signal Date: 2017-06-26 Impact factor: 8.401

Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease.

Review 1. RAGE and glyoxalase in kidney disease.

2. A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification.

3. Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration.

4. Ferulic acid prevents methylglyoxal-induced protein glycation, DNA damage, and apoptosis in pancreatic β-cells.

Review 5. Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases.

Review 6. Diabetes Mellitus as a Risk Factor for Parkinson's Disease: a Molecular Point of View.

7. Nitration and Glycation Turn Mature NGF into a Toxic Factor for Motor Neurons: A Role for p75^NTR and RAGE Signaling in ALS.

Review 8. Mechanistic targeting of advanced glycation end-products in age-related diseases.

Review 9. Too sweet: Problems of protein glycation in the eye.

Review 10. The role of dietary carbohydrates in organismal aging.

Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease.

Review 1. RAGE and glyoxalase in kidney disease.

2. A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification.

3. Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration.

4. Ferulic acid prevents methylglyoxal-induced protein glycation, DNA damage, and apoptosis in pancreatic β-cells.

Review 5. Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases.

Review 6. Diabetes Mellitus as a Risk Factor for Parkinson's Disease: a Molecular Point of View.

7. Nitration and Glycation Turn Mature NGF into a Toxic Factor for Motor Neurons: A Role for p75NTR and RAGE Signaling in ALS.

Review 8. Mechanistic targeting of advanced glycation end-products in age-related diseases.

Review 9. Too sweet: Problems of protein glycation in the eye.

Review 10. The role of dietary carbohydrates in organismal aging.

7. Nitration and Glycation Turn Mature NGF into a Toxic Factor for Motor Neurons: A Role for p75^NTR and RAGE Signaling in ALS.