| Literature DB >> 25666823 |
Minna Bui1, Xiaolin Hao1, Youngsook Shin1, Mario Cardozo1, Xiao He1, Kirk Henne2, Julia Suchomel1, John McCarter3, Lawrence R McGee1, Tisha San Miguel4, Julio C Medina1, Deanna Mohn4, Thuy Tran2, Sharon Wannberg4, Jamie Wong2, Simon Wong2, Leeanne Zalameda4, Daniela Metz4, Timothy D Cushing1.
Abstract
2,3,4-Substituted quinolines such as (10a) were found to be potent inhibitors of PI3Kδ in both biochemical and cellular assays with good selectivity over three other class I PI3K isoforms. Some of those analogs showed favorable pharmacokinetic properties.Entities:
Keywords: Autoimmune disorders; Inflammation; PI3Kδ; Reversed quinolines
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Year: 2015 PMID： 25666823 DOI： 10.1016/j.bmcl.2015.01.001
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823