Przemyslaw Zadora1, Wojciech Dabrowski2, Katarzyna Czarko1, Agata Smolen3, Edyta Kotlinska-Hasiec1, Krzysztof Wiorkowski1, Agnieszka Sikora1, Bozena Jarosz4, Krzysztof Kura4, Radosław Rola5, Tomasz Trojanowski4. 1. Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, Lublin, Poland. 2. Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, Lublin, Poland. Electronic address: w.dabrowski5@yahoo.com. 3. Department of Epidemiology, Medical University of Lublin, Lublin, Poland. 4. Department of Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, Lublin, Poland. 5. Department of Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, Lublin, Poland; Department of Physiopathology, Institute of Agricultural Medicine, Lublin, Poland.
Abstract
UNLABELLED: Neutrophil-lymphocyte count ratio (NLCR) is a recognized prognostic marker for renal, lung or colorectal carcinomas. The aim of the present study was to determine whether the preoperative value of NLCR might serve as a predictive marker for glial tumors' grading. METHODS: The retrospective analysis of NLCR was performed in neurosurgical patients treated for glial brain tumors. The preoperative NLCR was analyzed in accordance with WHO glial tumors' classification, which distinguishes G1, G2, G3 and G4 (glioblastoma) tumors. RESULTS: The analysis of NLCR was performed in 424 patients (258 males and 166 females) aged 53 ± 16 years who underwent either an open surgery or stereotactic biopsy for a glial brain tumor. G1 was diagnosed in 22 patients, G2 - in 71 patients, G3 - in 63 patients and G4 - in 268 patients. The highest value of NLCR was noted in G4 patients (5.08 [3.1; 8.7] - median [quartiles 1 and 3, respectively]) and was significantly higher compared to G3 (p<0.01), G2 (p<0.001) and G1 (p<0.01) groups. Moreover, NLCR was significantly higher in group G3 than G2 (p<0.05). ROC curve analysis showed 2.579 as a cut-off point for prediction of glioblastoma. CONCLUSION: Preoperative NLCR measurement corresponds with a glial brain tumor grading.
UNLABELLED: Neutrophil-lymphocyte count ratio (NLCR) is a recognized prognostic marker for renal, lung or colorectal carcinomas. The aim of the present study was to determine whether the preoperative value of NLCR might serve as a predictive marker for glial tumors' grading. METHODS: The retrospective analysis of NLCR was performed in neurosurgical patients treated for glial brain tumors. The preoperative NLCR was analyzed in accordance with WHO glial tumors' classification, which distinguishes G1, G2, G3 and G4 (glioblastoma) tumors. RESULTS: The analysis of NLCR was performed in 424 patients (258 males and 166 females) aged 53 ± 16 years who underwent either an open surgery or stereotactic biopsy for a glial brain tumor. G1 was diagnosed in 22 patients, G2 - in 71 patients, G3 - in 63 patients and G4 - in 268 patients. The highest value of NLCR was noted in G4 patients (5.08 [3.1; 8.7] - median [quartiles 1 and 3, respectively]) and was significantly higher compared to G3 (p<0.01), G2 (p<0.001) and G1 (p<0.01) groups. Moreover, NLCR was significantly higher in group G3 than G2 (p<0.05). ROC curve analysis showed 2.579 as a cut-off point for prediction of glioblastoma. CONCLUSION: Preoperative NLCR measurement corresponds with a glial brain tumor grading.
Authors: John K Wiencke; Devin C Koestler; Karl T Kelsey; Margaret R Wrensch; Brock C Christensen; Lucas A Salas; Joseph L Wiemels; Ritu P Roy; Helen M Hansen; Terri Rice; Lucie S McCoy; Paige M Bracci; Annette M Molinaro Journal: Clin Epigenetics Date: 2017-02-02 Impact factor: 6.551
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