Literature DB >> 25666673

Metabolic vulnerability in melanoma: a ME2 (me too) story.

Bin Zheng1, David E Fisher2.   

Abstract

Metabolic reprograming is a hallmark of cancer and might represent an Achilles' heel in cancer cells. The study by Chang et al. in this issue highlights a critical role of mitochondrial malic enzyme 2 (ME2) in melanoma progression. Targeting ME2 could be an effective approach to inhibit melanoma cell proliferation and tumor growth.

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Year:  2015        PMID： 25666673      PMCID： PMC4689190          DOI： 10.1038/jid.2014.449

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  10 in total

1.  Loss of AMPKα1 expression is associated with poor survival in melanoma patients.

Authors:  Madhuri Bhandaru; Magdalena Martinka; Gang Li; Anand Rotte
Journal:  J Invest Dermatol       Date:  2014-01-17       Impact factor: 8.551

Review 2.  AMPK: a nutrient and energy sensor that maintains energy homeostasis.

Authors:  D Grahame Hardie; Fiona A Ross; Simon A Hawley
Journal:  Nat Rev Mol Cell Biol       Date:  2012-03-22       Impact factor: 94.444

Review 3.  Molecular pathways: BRAF induces bioenergetic adaptation by attenuating oxidative phosphorylation.

Authors:  Rizwan Haq; David E Fisher; Hans R Widlund
Journal:  Clin Cancer Res       Date:  2014-03-07       Impact factor: 12.531

4.  Structure and function of malic enzymes, a new class of oxidative decarboxylases.

Authors:  Gu-Gang Chang; Liang Tong
Journal:  Biochemistry       Date:  2003-11-11       Impact factor: 3.162

5.  Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation.

Authors:  Bin Zheng; Joseph H Jeong; John M Asara; Yuan-Ying Yuan; Scott R Granter; Lynda Chin; Lewis C Cantley
Journal:  Mol Cell       Date:  2009-01-30       Impact factor: 17.970

6.  A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.

Authors:  Joanna Kaplon; Liang Zheng; Katrin Meissl; Barbara Chaneton; Vitaly A Selivanov; Gillian Mackay; Sjoerd H van der Burg; Elizabeth M E Verdegaal; Marta Cascante; Tomer Shlomi; Eyal Gottlieb; Daniel S Peeper
Journal:  Nature       Date:  2013-05-19       Impact factor: 49.962

7.  Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma.

Authors:  Ping Yuan; Koichi Ito; Rolando Perez-Lorenzo; Christina Del Guzzo; Jung Hyun Lee; Che-Hung Shen; Marcus W Bosenberg; Martin McMahon; Lewis C Cantley; Bin Zheng
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-21       Impact factor: 11.205

Review 8.  Understanding the Warburg effect: the metabolic requirements of cell proliferation.

Authors:  Matthew G Vander Heiden; Lewis C Cantley; Craig B Thompson
Journal:  Science       Date:  2009-05-22       Impact factor: 47.728

9.  Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling.

Authors:  Jian-Guo Ren; Pankaj Seth; Clary B Clish; Pawel K Lorkiewicz; Richard M Higashi; Andrew N Lane; Teresa W-M Fan; Vikas P Sukhatme
Journal:  Sci Rep       Date:  2014-06-24       Impact factor: 4.379

10.  Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence.

Authors:  Peng Jiang; Wenjing Du; Anthony Mancuso; Kathryn E Wellen; Xiaolu Yang
Journal:  Nature       Date:  2013-01-13       Impact factor: 49.962
  10 in total
  2 in total

1.  A small-molecule inhibitor suppresses the tumor-associated mitochondrial NAD(P)+-dependent malic enzyme (ME2) and induces cellular senescence.

Authors:  Ju-Yi Hsieh; Shao-Yu Li; Wen-Chen Tsai; Jyung-Hurng Liu; Chih-Li Lin; Guang-Yaw Liu; Hui-Chih Hung
Journal:  Oncotarget       Date:  2015-08-21

Review 2.  NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications.

Authors:  Huai-Qiang Ju; Jin-Fei Lin; Tian Tian; Dan Xie; Rui-Hua Xu
Journal:  Signal Transduct Target Ther       Date:  2020-10-07
  2 in total

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