Literature DB >> 25666573

Mitochondrial genomes and exceptional longevity in a Chinese population: the Rugao longevity study.

Lei Li1, Hong-Xiang Zheng, Zuyun Liu, Zhendong Qin, Fei Chen, Degui Qian, Jun Xu, Li Jin, Xiaofeng Wang.   

Abstract

Genetic variants of whole mitochondrial DNA (mtDNA) that predispose to exceptional longevity need to be systematically identified and appraised. Here, we conducted a case-control study with 237 exceptional longevity subjects (aged 95-107) and 444 control subjects (aged 40-69) randomly recruited from a "longevity town"-the city of Rugao in China-to investigate the effects of mtDNA variants on exceptional longevity. We sequenced the entire mtDNA genomes of the 681 subjects using a next-generation platform and employed a complete mtDNA phylogenetic analytical strategy. We identified T3394C as a candidate that counteracts longevity, and we observed a higher load of private nonsynonymous mutations in the COX1 gene predisposing to female longevity. Additionally, for the first time, we identified several variants and new subhaplogroups related to exceptional longevity. Our results provide new clues for genetic mechanisms of longevity and shed light on strategies for evaluating rare mitochondrial variants that underlie complex traits.

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Year:  2015        PMID： 25666573      PMCID： PMC4322039          DOI： 10.1007/s11357-015-9750-8

Source DB:  PubMed          Journal:  Age (Dordr)        ISSN： 0161-9152


  49 in total

1.  Effects of purifying and adaptive selection on regional variation in human mtDNA.

Authors:  Eduardo Ruiz-Pesini; Dan Mishmar; Martin Brandon; Vincent Procaccio; Douglas C Wallace
Journal:  Science       Date:  2004-01-09       Impact factor: 47.728

2.  Association of the mitochondrial DNA haplogroup J with longevity is population specific.

Authors:  Serena Dato; Giuseppe Passarino; Giuseppina Rose; Katia Altomare; Dina Bellizzi; Vincenzo Mari; Emidio Feraco; Claudio Franceschi; Giovanna De Benedictis
Journal:  Eur J Hum Genet       Date:  2004-12       Impact factor: 4.246

3.  Enrichment of longevity phenotype in mtDNA haplogroups D4b2b, D4a, and D5 in the Japanese population.

Authors:  Gabriela Alexe; Noriyuki Fuku; Erhan Bilal; Hitomi Ueno; Yutaka Nishigaki; Yasunori Fujita; Masafumi Ito; Yasumichi Arai; Nobuyoshi Hirose; Gyan Bhanot; Masashi Tanaka
Journal:  Hum Genet       Date:  2007-02-17       Impact factor: 4.132

Review 4.  20 years of human mtDNA pathologic point mutations: carefully reading the pathogenicity criteria.

Authors:  Julio Montoya; Ester López-Gallardo; Carmen Díez-Sánchez; Manuel J López-Pérez; Eduardo Ruiz-Pesini
Journal:  Biochim Biophys Acta       Date:  2008-09-18

5.  Association of mtDNA haplogroup F with healthy longevity in the female Chuang population, China.

Authors:  Jie Feng; Jianyi Zhang; Ming Liu; Gang Wan; Keyan Qi; Chenguang Zheng; Zeping Lv; Caiyou Hu; Yi Zeng; Simon G Gregory; Ze Yang
Journal:  Exp Gerontol       Date:  2011-09-16       Impact factor: 4.032

6.  Evolution and functional impact of rare coding variation from deep sequencing of human exomes.

Authors:  Jacob A Tennessen; Abigail W Bigham; Timothy D O'Connor; Wenqing Fu; Eimear E Kenny; Simon Gravel; Sean McGee; Ron Do; Xiaoming Liu; Goo Jun; Hyun Min Kang; Daniel Jordan; Suzanne M Leal; Stacey Gabriel; Mark J Rieder; Goncalo Abecasis; David Altshuler; Deborah A Nickerson; Eric Boerwinkle; Shamil Sunyaev; Carlos D Bustamante; Michael J Bamshad; Joshua M Akey
Journal:  Science       Date:  2012-05-17       Impact factor: 47.728

7.  Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans.

Authors:  G De Benedictis; G Rose; G Carrieri; M De Luca; E Falcone; G Passarino; M Bonafe; D Monti; G Baggio; S Bertolini; D Mari; R Mattace; C Franceschi
Journal:  FASEB J       Date:  1999-09       Impact factor: 5.191

8.  Cosegregation of novel mitochondrial 16S rRNA gene mutations with the age-associated T414G variant in human cybrids.

Authors:  Peter Seibel; Chiara Di Nunno; Christian Kukat; Ingo Schäfer; Roberto Del Bo; Andreina Bordoni; Giacomo P Comi; Astrid Schön; Ferdinando Capuano; Dominga Latorre; Gaetano Villani
Journal:  Nucleic Acids Res       Date:  2008-09-16       Impact factor: 16.971

9.  Multiplex sequencing of plant chloroplast genomes using Solexa sequencing-by-synthesis technology.

Authors:  Richard Cronn; Aaron Liston; Matthew Parks; David S Gernandt; Rongkun Shen; Todd Mockler
Journal:  Nucleic Acids Res       Date:  2008-08-27       Impact factor: 16.971

10.  The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific.

Authors:  Nicola Raule; Federica Sevini; Shengting Li; Annalaura Barbieri; Federica Tallaro; Laura Lomartire; Dario Vianello; Alberto Montesanto; Jukka S Moilanen; Vladyslav Bezrukov; Hélène Blanché; Antti Hervonen; Kaare Christensen; Luca Deiana; Efstathios S Gonos; Tom B L Kirkwood; Peter Kristensen; Alberta Leon; Pier Giuseppe Pelicci; Michel Poulain; Irene M Rea; Josè Remacle; Jean Marie Robine; Stefan Schreiber; Ewa Sikora; Peternella Eline Slagboom; Liana Spazzafumo; Maria Antonietta Stazi; Olivier Toussaint; James W Vaupel; Giuseppina Rose; Kari Majamaa; Markus Perola; Thomas E Johnson; Lars Bolund; Huanming Yang; Giuseppe Passarino; Claudio Franceschi
Journal:  Aging Cell       Date:  2013-12-17       Impact factor: 9.304
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  6 in total

Review 1.  Genetic and epigenetic regulation of human aging and longevity.

Authors:  Brian J Morris; Bradley J Willcox; Timothy A Donlon
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2018-09-01       Impact factor: 5.187

2.  MtDNA genomes reveal a relaxation of selective constraints in low-BMI individuals in a Uyghur population.

Authors:  Hong-Xiang Zheng; Lei Li; Xiao-Yan Jiang; Shi Yan; Zhendong Qin; Xiaofeng Wang; Li Jin
Journal:  Hum Genet       Date:  2017-08-10       Impact factor: 4.132

3.  MtDNA analysis reveals enriched pathogenic mutations in Tibetan highlanders.

Authors:  Longli Kang; Hong-Xiang Zheng; Menghan Zhang; Shi Yan; Lei Li; Lijun Liu; Kai Liu; Kang Hu; Feng Chen; Lifeng Ma; Zhendong Qin; Yi Wang; Xiaofeng Wang; Li Jin
Journal:  Sci Rep       Date:  2016-08-08       Impact factor: 4.379

4.  Compatibility between mitochondrial and nuclear genomes correlates with the quantitative trait of lifespan in Caenorhabditis elegans.

Authors:  Zuobin Zhu; Qing Lu; Fangfang Zeng; Junjing Wang; Shi Huang
Journal:  Sci Rep       Date:  2015-11-25       Impact factor: 4.379

5.  Bagging Nearest-Neighbor Prediction independence Test: an efficient method for nonlinear dependence of two continuous variables.

Authors:  Yi Wang; Yi Li; Xiaoyu Liu; Weilin Pu; Xiaofeng Wang; Jiucun Wang; Momiao Xiong; Yin Yao Shugart; Li Jin
Journal:  Sci Rep       Date:  2017-10-06       Impact factor: 4.379

6.  Common mtDNA variations at C5178a and A249d/T6392C/G10310A decrease the risk of severe COVID-19 in a Han Chinese population from Central China.

Authors:  Yi Wu; Xian-Hui Wang; Xi-Hua Li; Li-Yuan Song; Shi-Long Yu; Zhi-Cheng Fang; Yu-Quan Liu; Le-Yong Yuan; Chun-Yan Peng; Shen-Yi Zhang; Wang Cheng; Hong-Chao Ma; Li-Feng Wang; Jun-Ming Tang; Yun-Fu Wang; Fu-Yun Ji
Journal:  Mil Med Res       Date:  2021-11-01
  6 in total

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