Literature DB >> 25666338

Three-component synthesis of fluorinated pyrazoles from fluoroalkylamines, NaNO2 and electron-deficient alkynes.

Pavel K Mykhailiuk1.   

Abstract

Three-component reaction between RCF2CH2NH2·HCl, NaNO2 and electron-deficient alkynes significantly depends on substituent "R". The reaction gives the fluorinated pyrazoles in high yields when "R" is a fluorine atom or a fluoroalkyl group. With other "R" unexpected products are formed.

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Year:  2015        PMID： 25666338     DOI： 10.1039/c4ob02670e

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  2 in total

1.  Trifluoromethylated Pyrazoles via Sequential (3 + 2)-Cycloaddition of Fluorinated Nitrile Imines with Chalcones and Solvent-Dependent Deacylative Oxidation Reactions.

Authors:  Anna Kowalczyk; Greta Utecht-Jarzyńska; Grzegorz Mlostoń; Marcin Jasiński
Journal:  Org Lett       Date:  2022-03-28       Impact factor: 6.005

Review 2.  Diazoacetonitrile (N2 CHCN): A Long Forgotten but Valuable Reagent for Organic Synthesis.

Authors:  Pavel K Mykhailiuk; Rene M Koenigs
Journal:  Chemistry       Date:  2019-10-15       Impact factor: 5.236
  2 in total

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