Literature DB >> 25666094

Tregalizumab (BT-061) increases regulatory T cell function. Boosting regulatory T-cell function with the humanized CD4-specific humanized monoclonal antibody Tregalizumab (BT-061).

Stéphanie Humblet-Baron1, Frédéric Baron2.   

Abstract

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Year:  2015        PMID： 25666094     DOI： 10.1038/icb.2014.120

Source DB:  PubMed          Journal:  Immunol Cell Biol        ISSN： 0818-9641            Impact factor:   5.126


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  14 in total

Review 1.  TREG-cell therapies for autoimmune rheumatic diseases.

Authors:  Makoto Miyara; Yoshinaga Ito; Shimon Sakaguchi
Journal:  Nat Rev Rheumatol       Date:  2014-07-01       Impact factor: 20.543

2.  Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

Authors:  S Sakaguchi; N Sakaguchi; M Asano; M Itoh; M Toda
Journal:  J Immunol       Date:  1995-08-01       Impact factor: 5.422

3.  HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse.

Authors:  Massimo F Martelli; Mauro Di Ianni; Loredana Ruggeri; Franca Falzetti; Alessandra Carotti; Adelmo Terenzi; Antonio Pierini; Maria Speranza Massei; Lucia Amico; Elena Urbani; Beatrice Del Papa; Tiziana Zei; Roberta Iacucci Ostini; Debora Cecchini; Rita Tognellini; Yair Reisner; Franco Aversa; Brunangelo Falini; Andrea Velardi
Journal:  Blood       Date:  2014-06-12       Impact factor: 22.113

4.  Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals.

Authors:  C T Mayer; L Tian; C Hesse; A A Kühl; M Swallow; F Kruse; M Thiele; M E Gershwin; A Liston; T Sparwasser
Journal:  J Autoimmun       Date:  2013-09-25       Impact factor: 7.094

5.  Continuous requirement for the TCR in regulatory T cell function.

Authors:  Andrew G Levine; Aaron Arvey; Wei Jin; Alexander Y Rudensky
Journal:  Nat Immunol       Date:  2014-09-28       Impact factor: 25.606

6.  Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease.

Authors:  Ken-ichi Matsuoka; John Koreth; Haesook T Kim; Gregory Bascug; Sean McDonough; Yutaka Kawano; Kazuyuki Murase; Corey Cutler; Vincent T Ho; Edwin P Alyea; Philippe Armand; Bruce R Blazar; Joseph H Antin; Robert J Soiffer; Jerome Ritz
Journal:  Sci Transl Med       Date:  2013-04-03       Impact factor: 17.956

Review 7.  Current issues in chronic graft-versus-host disease.

Authors:  Gérard Socié; Jerome Ritz
Journal:  Blood       Date:  2014-06-09       Impact factor: 22.113

8.  Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets - results of one year follow-up.

Authors:  Natalia Marek-Trzonkowska; Małgorzata Myśliwiec; Anita Dobyszuk; Marcelina Grabowska; Ilona Derkowska; Jolanta Juścińska; Radosław Owczuk; Agnieszka Szadkowska; Piotr Witkowski; Wojciech Młynarski; Przemysława Jarosz-Chobot; Artur Bossowski; Janusz Siebert; Piotr Trzonkowski
Journal:  Clin Immunol       Date:  2014-04-01       Impact factor: 3.969

9.  Boosting regulatory T cell function by CD4 stimulation enters the clinic.

Authors:  Christian Becker; Tobias Bopp; Helmut Jonuleit
Journal:  Front Immunol       Date:  2012-06-18       Impact factor: 7.561

10.  A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway.

Authors:  Bianca Helling; Martin König; Benjamin Dälken; Andre Engling; Wolfgang Krömer; Katharina Heim; Holger Wallmeier; Jürgen Haas; Brigitte Wildemann; Brigitte Fritz; Helmut Jonuleit; Jan Kubach; Theodor Dingermann; Heinfried H Radeke; Frank Osterroth; Christoph Uherek; Niklas Czeloth; Jörg Schüttrumpf
Journal:  Immunol Cell Biol       Date:  2014-12-16       Impact factor: 5.126
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  1 in total

1.  Impact of Pre-Transplant Anti-T Cell Globulin (ATG) on Immune Recovery after Myeloablative Allogeneic Peripheral Blood Stem Cell Transplantation.

Authors:  Sophie Servais; Catherine Menten-Dedoyart; Yves Beguin; Laurence Seidel; André Gothot; Coline Daulne; Evelyne Willems; Loïc Delens; Stéphanie Humblet-Baron; Muriel Hannon; Frédéric Baron
Journal:  PLoS One       Date:  2015-06-22       Impact factor: 3.240
  1 in total

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