Literature DB >> 25665853

CD40 expression and its prognostic significance in human gastric carcinoma.

Jing Guo1, Jia-Jia Xiao, Xiaoli Zhang, Kai-Xi Fan.   

Abstract

This study aimed to detect the relationship between CD40 (protein and mRNA) expression and human gastric cancer and to determine the prognostic significance of CD40 in gastric cancer patients. We collected 128 cases of gastric cancer specimens, and the expression of CD40 (protein and mRNA) was measured by immunohistochemistry and in situ hybridization. Our study indicated that CD40 is constitutively expressed in human gastric carcinoma tissues. Positive expression of CD40 (protein and mRNA) in gastric cancer tissues was closely related to the tumor TNM stage and the presence of distant metastasis, with CD40 mRNA also being correlated with the presence of lymphatic metastasis. Furthermore, the expression of CD40 (protein and mRNA) is closely related to the prognosis of gastric cancer patients. The expression of CD40 protein and mRNA is positively correlated with the presence of distant (for both protein and mRNA) and lymphatic (for mRNA only) metastasis, and an increased tumor TNM stage in gastric carcinoma. Patients who express low levels of CD40 may have a better prognosis than those who have higher levels of CD40.

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Year:  2015        PMID： 25665853     DOI： 10.1007/s12032-014-0463-0

Source DB:  PubMed          Journal:  Med Oncol        ISSN： 1357-0560            Impact factor:   3.064


  24 in total

1.  Molecular characterization of CD40 signaling intermediates.

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Journal:  J Biol Chem       Date:  2001-09-18       Impact factor: 5.157

2.  CD40-dependent activation of phosphatidylinositol 3-kinase/Akt pathway mediates endothelial cell survival and in vitro angiogenesis.

Authors:  Maria Chiara Deregibus; Stefano Buttiglieri; Simona Russo; Benedetta Bussolati; Giovanni Camussi
Journal:  J Biol Chem       Date:  2003-03-12       Impact factor: 5.157

3.  The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells.

Authors:  Mohammad Luqman; Sha Klabunde; Karen Lin; Georgios V Georgakis; Anu Cherukuri; Jocelyn Holash; Cheryl Goldbeck; Xiaomei Xu; Edward E Kadel; Sang Hoon Lee; Sharon Lea Aukerman; Bahija Jallal; Natasha Aziz; Wen-Kai Weng; William Wierda; Susan O'Brien; Anas Younes
Journal:  Blood       Date:  2008-05-22       Impact factor: 22.113

4.  KAI1/CD82 and MRP1/CD9 serve as markers of infiltration, metastasis, and prognosis in laryngeal squamous cell carcinomas.

Authors:  Bing-Hui Zhang; Wei Liu; Liang Li; Jian-Guang Lu; Ya-Nan Sun; De-Jun Jin; Xiu-Yu Xu
Journal:  Asian Pac J Cancer Prev       Date:  2013

Review 5.  [Research advances of anti-CD40 monoclonal antibody].

Authors:  Long-Long Luo; Yan Zhang; Chun-Mei Hou; Chun-Xia Qiao; Yan Li
Journal:  Zhongguo Shi Yan Xue Ye Xue Za Zhi       Date:  2013-04

6.  Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody.

Authors:  Robert H Vonderheide; Keith T Flaherty; Magi Khalil; Molly S Stumacher; David L Bajor; Natalie A Hutnick; Patricia Sullivan; J Joseph Mahany; Maryann Gallagher; Amy Kramer; Stephanie J Green; Peter J O'Dwyer; Kelli L Running; Richard D Huhn; Scott J Antonia
Journal:  J Clin Oncol       Date:  2007-03-01       Impact factor: 44.544

7.  Role for CD40-CD40 ligand interactions in the immune response to solid tumours.

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Journal:  Mol Immunol       Date:  2000-06       Impact factor: 4.407

8.  PI3K/Akt activity has variable cell-specific effects on expression of HIF target genes, CA9 and VEGF, in human cancer cell lines.

Authors:  Norazizah Shafee; Stefan Kaluz; Ning Ru; Eric J Stanbridge
Journal:  Cancer Lett       Date:  2009-04-01       Impact factor: 8.679

9.  FLICE-inhibitory protein is a key regulator of germinal center B cell apoptosis.

Authors:  A Hennino; M Bérard; P H Krammer; T Defrance
Journal:  J Exp Med       Date:  2001-02-19       Impact factor: 14.307

10.  Macrophages and Fc-receptor interactions contribute to the antitumour activities of the anti-CD40 antibody SGN-40.

Authors:  E Oflazoglu; I J Stone; L Brown; K A Gordon; N van Rooijen; M Jonas; C-L Law; I S Grewal; H-P Gerber
Journal:  Br J Cancer       Date:  2008-12-09       Impact factor: 7.640
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  5 in total

Review 1.  Promising therapeutics of gastrointestinal cancers in clinical trials.

Authors:  Lingling Du; Zheng Che; Andrea Wang-Gillam
Journal:  J Gastrointest Oncol       Date:  2017-06

2.  Clinicopathological features of gastric adenocarcinoma patients with metachronous distant metastasis.

Authors:  Junjie Bao; Guofan Qu; Wangshu Fu; Yanjing Li; Haibin Song; Yuzhe Wei; Yingwei Xue
Journal:  Tumour Biol       Date:  2015-04-29

3.  Helicobacter pylori Infection-Related Long Non-Coding RNA Signatures Predict the Prognostic Status for Gastric Cancer Patients.

Authors:  Zhuoyuan Xin; Luping Zhang; Mingqing Liu; Yachen Wang; Yingli Zhang; Weidan Zhao; Yongxiao Sun; Lei Shi; Na Xu; Nan Zhang; Hong Xu
Journal:  Front Oncol       Date:  2021-07-27       Impact factor: 6.244

4.  Somatic Mutation of FAT Family Genes Implicated Superior Prognosis in Patients With Stomach Adenocarcinoma.

Authors:  Qingjun Wang; Liang Cui; Pansong Li; Yuanyuan Wang
Journal:  Front Med (Lausanne)       Date:  2022-06-28

5.  CD40 is Positively Correlated with the Expression of Nucleophosmin in Cisplatin-Resistant Bladder Cancer.

Authors:  Chenshuo Luo; Ting Lei; Man Zhao; Qian Meng; Man Zhang
Journal:  J Oncol       Date:  2020-04-28       Impact factor: 4.375
  5 in total

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