Jon D Elhai1, Ateka A Contractor2, Marijo Tamburrino3, Thomas H Fine3, Gregory Cohen4, Edwin Shirley5, Philip K Chan5, Israel Liberzon6, Joseph R Calabrese7, Sandro Galea8. 1. Department of Psychology, University of Toledo, United States; Department of Psychiatry, University of Toledo, United States. 2. Department of Psychology, University of Toledo, United States. 3. Department of Psychiatry, University of Toledo, United States. 4. Department of Epidemiology, Columbia University, United States. 5. Department of Psychiatry, Case Western Reserve University, United States; University Hospitals Case Medical Center, United States. 6. VA Ann Arbor Health System, Ann Arbor, Michigan, United States; Department of Psychiatry, University of Michigan, United States. 7. Department of Psychiatry, Case Western Reserve University, United States. 8. School of Public Health, Boston University, United States.
Abstract
BACKGROUND: Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are frequently comorbid. One explanation for this comorbidity is that PTSD has a constellation of "dysphoria" symptoms resembling depression. METHOD: Using confirmatory factor analysis we tested the role of DSM-5 PTSD׳s dysphoria factor in relation to MDD symptom dimensions of somatic and non-somatic psychopathology. 672 Ohio National Guard soldiers completed DSM-5 measures of PTSD and MDD symptoms in an epidemiological study. RESULTS: Results indicated that in contrast to other PTSD factors, PTSD׳s dysphoria factor was more related to MDD׳s somatic and non-somatic factors. LIMITATIONS: Limitations include generalizability to the epidemiological population of trauma-exposed military veterans rather than civilians, and reliance on self-report measures. CONCLUSIONS: Implications concerning clinical psychopathology and comorbidity of PTSD are discussed, including whether PTSD should be refined by removing its non-specific symptoms.
BACKGROUND:Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are frequently comorbid. One explanation for this comorbidity is that PTSD has a constellation of "dysphoria" symptoms resembling depression. METHOD: Using confirmatory factor analysis we tested the role of DSM-5 PTSD׳s dysphoria factor in relation to MDD symptom dimensions of somatic and non-somatic psychopathology. 672 Ohio National Guard soldiers completed DSM-5 measures of PTSD and MDD symptoms in an epidemiological study. RESULTS: Results indicated that in contrast to other PTSD factors, PTSD׳s dysphoria factor was more related to MDD׳s somatic and non-somatic factors. LIMITATIONS: Limitations include generalizability to the epidemiological population of trauma-exposed military veterans rather than civilians, and reliance on self-report measures. CONCLUSIONS: Implications concerning clinical psychopathology and comorbidity of PTSD are discussed, including whether PTSD should be refined by removing its non-specific symptoms.
Authors: Murray B Stein; Chia-Yen Chen; Robert J Ursano; Tianxi Cai; Joel Gelernter; Steven G Heeringa; Sonia Jain; Kevin P Jensen; Adam X Maihofer; Colter Mitchell; Caroline M Nievergelt; Matthew K Nock; Benjamin M Neale; Renato Polimanti; Stephan Ripke; Xiaoying Sun; Michael L Thomas; Qian Wang; Erin B Ware; Susan Borja; Ronald C Kessler; Jordan W Smoller Journal: JAMA Psychiatry Date: 2016-07-01 Impact factor: 21.596
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