Robert M Goulding1, Nathan J Stevenson1, Deirdre M Murray1, Vicki Livingstone1, Peter M Filan2, Geraldine B Boylan1. 1. 1] Neonatal Brain Research Group, Irish Centre for Fetal and Neonatal Translational Research, Cork, Ireland [2] Department of Paediatrics & Child Health, University College Cork, Cork, Ireland. 2. 1] Neonatal Brain Research Group, Irish Centre for Fetal and Neonatal Translational Research, Cork, Ireland [2] Neonatal Intensive Care Unit, Cork University Maternity Hospital, Cork, Ireland.
Abstract
BACKGROUND: The study aims to describe heart rate variability (HRV) in neonatal hypoxic ischemic encephalopathy (HIE) and correlate HRV with electroencephalographic (EEG) grade of HIE and neurodevelopmental outcome. METHODS: Multichannel EEG and electrocardiography (ECG) were assessed at 12-48 h after birth in healthy and encephalopathic full-term neonates. EEGs were graded (normal, mild, moderate, and severe). Neurodevelopmental outcome was assessed at 2 y of age. Seven HRV features were calculated using normalized-RR (NN) interval. The correlation of these features with EEG grade and outcome were measured using Spearman's correlation coefficient. RESULTS: HRV was significantly associated with HIE severity (P < 0.05): standard deviation of NN interval (SDNN) (r = -0.62), triangular interpolation of NN interval histogram (TINN) (r = -0.65), mean NN interval (r = -0.48), and the very low frequency (VLF) (r = -0.60), low frequency (LF) (r = -0.67) and high frequency (HF) components of the NN interval (r = -0.60). SDNN at 24 and 48 h were significantly associated (P < 0.05) with neurodevelopmental outcome (r = -0.41 and -0.54, respectively). CONCLUSION: HRV is associated with EEG grade of HIE and neurodevelopmental outcome. HRV has potential as a prognostic tool to complement EEG.
BACKGROUND: The study aims to describe heart rate variability (HRV) in neonatal hypoxic ischemicencephalopathy (HIE) and correlate HRV with electroencephalographic (EEG) grade of HIE and neurodevelopmental outcome. METHODS: Multichannel EEG and electrocardiography (ECG) were assessed at 12-48 h after birth in healthy and encephalopathic full-term neonates. EEGs were graded (normal, mild, moderate, and severe). Neurodevelopmental outcome was assessed at 2 y of age. Seven HRV features were calculated using normalized-RR (NN) interval. The correlation of these features with EEG grade and outcome were measured using Spearman's correlation coefficient. RESULTS: HRV was significantly associated with HIE severity (P < 0.05): standard deviation of NN interval (SDNN) (r = -0.62), triangular interpolation of NN interval histogram (TINN) (r = -0.65), mean NN interval (r = -0.48), and the very low frequency (VLF) (r = -0.60), low frequency (LF) (r = -0.67) and high frequency (HF) components of the NN interval (r = -0.60). SDNN at 24 and 48 h were significantly associated (P < 0.05) with neurodevelopmental outcome (r = -0.41 and -0.54, respectively). CONCLUSION: HRV is associated with EEG grade of HIE and neurodevelopmental outcome. HRV has potential as a prognostic tool to complement EEG.
Authors: An N Massaro; Heather E Campbell; Marina Metzler; Tareq Al-Shargabi; Yunfei Wang; Adre du Plessis; Rathinaswamy B Govindan Journal: Pediatr Crit Care Med Date: 2017-04 Impact factor: 3.624
Authors: Emily Cohen; Flora Y Wong; Euan M Wallace; Joanne C Mockler; Alexsandria Odoi; Samantha Hollis; Rosemary S C Horne; Stephanie R Yiallourou Journal: Pediatr Res Date: 2017-04-07 Impact factor: 3.756
Authors: Robert M Goulding; Nathan J Stevenson; Deirdre M Murray; Vicki Livingstone; Peter M Filan; Geraldine B Boylan Journal: Pediatr Res Date: 2016-11-17 Impact factor: 3.756