Literature DB >> 25664646

RUNX3 Promoter Methylation Is Associated with Hepatocellular Carcinoma Risk: A Meta-Analysis.

Xueyan Zhang1, Hairong He, Xu Zhang, Wenjie Guo, Yueqi Wang.   

Abstract

Runt-related transcription factor 3 (RUNX3) has been reported to be a tumor-suppressing gene in hepatocellular carcinoma. Association between hepatocellular carcinoma and RUNX3 promoter methylation has been investigated in studies with specific ethnic backgrounds and small sample sizes. In this study, a meta-analysis was adopted to combine the data from 11 studies of association between RUNX3 promoter methylation and hepatocellular carcinoma. Pooled odds ratio for RUNX3 promoter methylation status in hepatocellular carcinoma versus control liver tissue was 24.37 (95%CI: 12.14, 48.92), p < .00001, indicates a strong association between methylation of the RUNX3 promoter and hepatocellular carcinoma.

Entities:  

Keywords:  Confidence intervals; RUNX3; Hepatocellular carcinoma; Meta-Analysis; Methylation; OR; Odds ratio; CI; Promoter; RUNX3; Runt-related transcription factor 3

Mesh：

Substances：

Year:  2015        PMID： 25664646     DOI： 10.3109/07357907.2014.1003934

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  7 in total

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2.  Transcriptome-Wide 5-Methylcytosine Functional Profiling of Long Non-Coding RNA in Hepatocellular Carcinoma.

Authors:  Yuting He; Qingmiao Shi; Yize Zhang; Xin Yuan; Zujiang Yu
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Authors:  Tao Huang; Jinyun Li; Cheng Zhang; Qingxiao Hong; Danjie Jiang; Meng Ye; Shiwei Duan
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4.  Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns.

Authors:  Annika Wahl; Erik van den Akker; Lucija Klaric; Jerko Štambuk; Elisa Benedetti; Rosina Plomp; Genadij Razdorov; Irena Trbojević-Akmačić; Joris Deelen; Diana van Heemst; P Eline Slagboom; Frano Vučković; Harald Grallert; Jan Krumsiek; Konstantin Strauch; Annette Peters; Thomas Meitinger; Caroline Hayward; Manfred Wuhrer; Marian Beekman; Gordan Lauc; Christian Gieger
Journal:  Front Immunol       Date:  2018-02-26       Impact factor: 7.561

5.  lncRNA MT1JP Suppresses Biological Activities of Breast Cancer Cells in vitro and in vivo by Regulating the miRNA-214/RUNX3 Axis.

Authors:  Qianwen Ouyang; Yanru Cui; Shixin Yang; Wensong Wei; Mingyue Zhang; Jie Zeng; Fei Qu
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6.  An Observational Study on Aberrant Methylation of Runx3 With the Prognosis in Chronic Atrophic Gastritis Patients.

Authors:  Chunna Zhao; Ping Li; Lili Zhang; Bei Wang; Lili Xiao; Feng Guo; Yueguang Wei
Journal:  Medicine (Baltimore)       Date:  2016-05       Impact factor: 1.889

7.  Methylation analysis of p16, SLIT2, SCARA5, and Runx3 genes in hepatocellular carcinoma.

Authors:  Gaofeng Sun; Chen Zhang; Min Feng; Wensheng Liu; Huifang Xie; Qin Qin; E Zhao; Li Wan
Journal:  Medicine (Baltimore)       Date:  2017-10       Impact factor: 1.817
  7 in total

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