Literature DB >> 25664358

Nuclease resistant oligonucleotides with cell penetrating properties.

Stefan Milton1, Dmytro Honcharenko, Cristina S J Rocha, Pedro M D Moreno, C I Edvard Smith, Roger Strömberg.   

Abstract

2'-O-AECM modified oligonucleotides provide an unusual combination of remarkable properties. This includes the combination of high resistance towards enzymatic degradation and the spontaneous cellular uptake of AECM oligonucleotides.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 25664358     DOI： 10.1039/c4cc08837a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  2'-O-(N-(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity.

Authors:  Dmytro Honcharenko; Cristina S J Rocha; Karin E Lundin; Jyotirmoy Maity; Stefan Milton; Ulf Tedebark; Merita Murtola; Malgorzata Honcharenko; Andis Slaitas; C I Edvard Smith; Rula Zain; Roger Strömberg
Journal:  Nucleic Acid Ther       Date:  2022-03-02       Impact factor: 4.244

2.  Oligonucleotides with Cationic Backbone and Their Hybridization with DNA: Interplay of Base Pairing and Electrostatic Attraction.

Authors:  Boris Schmidtgall; Arne Kuepper; Melissa Meng; Tom N Grossmann; Christian Ducho
Journal:  Chemistry       Date:  2017-12-27       Impact factor: 5.236

3.  Enhanced Stability of DNA Oligonucleotides with Partially Zwitterionic Backbone Structures in Biological Media.

Authors:  Melissa Meng; Boris Schmidtgall; Christian Ducho
Journal:  Molecules       Date:  2018-11-10       Impact factor: 4.411

Review 4.  Oligonucleotide analogues with cationic backbone linkages.

Authors:  Melissa Meng; Christian Ducho
Journal:  Beilstein J Org Chem       Date:  2018-06-04       Impact factor: 2.883

5.  Towards Zwitterionic Oligonucleotides with Improved Properties: the NAA/LNA-Gapmer Approach.

Authors:  Melissa Wojtyniak; Boris Schmidtgall; Philine Kirsch; Christian Ducho
Journal:  Chembiochem       Date:  2020-08-28       Impact factor: 3.164

6.  A Study on Synthesis and Upscaling of 2'-O-AECM-5-methyl Pyrimidine Phosphoramidites for Oligonucleotide Synthesis.

Authors:  Kristina Karalė; Martin Bollmark; Rouven Stulz; Dmytro Honcharenko; Ulf Tedebark; Roger Strömberg
Journal:  Molecules       Date:  2021-11-17       Impact factor: 4.411

7.  Synthesis of siRNAs incorporated with cationic peptides R8G7 and R8A7 and the effect of the modifications on siRNA properties.

Authors:  Miho Matsubara; Kenji Honda; Koki Ozaki; Ryohei Kajino; Yuri Kakisawa; Yusuke Maeda; Yoshihito Ueno
Journal:  RSC Adv       Date:  2020-09-21       Impact factor: 4.036
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.