Zhixiang Liu1, Peisen Zhang1, Jie Dong1. 1. Department of Nuclear Medicine, The Hospital Affiliated of Weifang Medical University Kuiwen Region 261031, Weifang City, Shandong Province, China.
Abstract
OBJECTIVE: Genetic factors play an important role in ankylosing spondylitis (AS) etiology and signal transducer and activator of transcription 4 (STAT4) gene polymorphisms may be involved. The aim of this study was to test whether STAT4 variants were associated with susceptibility to AS in a Chinese population. METHODS: A total of 175 subjects who were diagnosed as AS and 249 healthy age-matched controls were enrolled in the present study. The rs7574865 G/T SNP in STAT4 gene was genotyped in all the subjects. The SPSS software was used to investigate the association between the rs7574865 genotypes and AS susceptibility or severity. RESULTS: Rs7574865 G/T was found to be significantly associated with increased risk and severity of AS. CONCLUSION: Our data demonstrated the STAT4 rs7574865 G/T SNP was significantly associated with increased AS susceptibility and severity in Chinese Han Population.
OBJECTIVE: Genetic factors play an important role in ankylosing spondylitis (AS) etiology and signal transducer and activator of transcription 4 (STAT4) gene polymorphisms may be involved. The aim of this study was to test whether STAT4 variants were associated with susceptibility to AS in a Chinese population. METHODS: A total of 175 subjects who were diagnosed as AS and 249 healthy age-matched controls were enrolled in the present study. The rs7574865 G/T SNP in STAT4 gene was genotyped in all the subjects. The SPSS software was used to investigate the association between the rs7574865 genotypes and AS susceptibility or severity. RESULTS:Rs7574865 G/T was found to be significantly associated with increased risk and severity of AS. CONCLUSION: Our data demonstrated the STAT4rs7574865 G/T SNP was significantly associated with increased AS susceptibility and severity in Chinese Han Population.
Entities:
Keywords:
Ankylosing spondylitis; Chinese Han population; STAT4; gene polymorphism
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