Literature DB >> 25664047

Polymorphisms of FtsK/SpoIIIE protein in Mycobacterium tuberculosis complex strains may affect both protein function and host immune reaction.

Yi Jiang1, Haican Liu1, Yan Qiu1, Guilian Li1, Xiangfeng Dou2, Kanglin Wan1.   

Abstract

FtsK/SpoIIIE family ATPases are conserved throughout bacteria and are involved in the translocation of DNA and proteins through membrane-spanning pores. Through comparison of 26 whole-genome-sequenced M. tuberculosis complex (MTBC) strains downloaded from NCBI website, we found that FtsK/SpoIIIE protein presented polymorphisms. One M. bovis strain and three BCG strains even showed the two T cell epitopes missing. Then we chose 159 clinical M. tuberculosis isolates from China, amplified gene encoding FtsK/SpoIIIE protein (Rv3871) and compared the sequences. The results showed that there are polymorphisms existed in FtsK/SpoIIIE protein among MTBC, which may affect both protein function and host immune reaction. In addition, position 1497 could be used as a good phylogenetic marker for Beijing strains.

Entities:  

Keywords:  FtsK/SpoIIIE protein; Mycobacterium tuberculosis; polymorphisms

Year:  2014        PMID： 25664047      PMCID： PMC4307494     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


  12 in total

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4.  Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system.

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5.  Meeting Report: NIH Workshop on the Tuberculosis Immune Epitope Database.

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Authors:  Talia L Ramsdell; Laura A Huppert; Tatyana A Sysoeva; Sarah M Fortune; Briana M Burton
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  1 in total

1.  Conserved hypothetical protein Rv1977 in Mycobacterium tuberculosis strains contains sequence polymorphisms and might be involved in ongoing immune evasion.

Authors:  Yi Jiang; Haican Liu; Xuezhi Wang; Guilian Li; Yan Qiu; Xiangfeng Dou; Kanglin Wan
Journal:  Int J Clin Exp Pathol       Date:  2015-06-01
  1 in total

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