Literature DB >> 25664044

TLR4 +896A>G (Asp299Gly) polymorphism is not associated with asthma: a update meta-analysis.

Yingshui Yao1, Xiaohua Ren2, Lianping He2, Jie Li2, Yuelong Jin2, Weiwei Chang2, Chaopin Li3.   

Abstract

Some research reported that polymorphisms in the toll-Like receptor 4 may have influence on asthma risk. Here, we sought to estimate the effects of Toll-Like Receptor 4 (Asp299Gly) genes on asthma risk. Databases including PubMed and Chinese National Knowledge Infrastructure (CNKI) databases were searched to find relevant studies. The odds ratio (OR) with corresponding 95% confidence intervals (CIs) was performed. A total of 12 case-control studies were finally identified. This meta-analysis indicated that no significant association was found between TLR4 (Asp299Gly) genes and asthma risk (OR = 0.91, 95% CI = 0.71-1.12). In conclusion, our findings suggest that TLR4 +896A>G (Asp299Gly) polymorphism may not contribute to the risk of asthma.

Entities:  

Keywords:  Toll-Like Receptor 4; asthma; meta-analysis; polymorphism; single nucleotide polymorphism

Year:  2014        PMID： 25664044      PMCID： PMC4307491     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


  22 in total

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  2 in total

1.  Association of TLR4 (896A/G and 1196C/T) Gene Polymorphisms with Asthma Risk: A Meta-Analysis.

Authors:  Shaojun Li; Xinming Xie; Yang Song; Haoxiang Jiang; Xiaojuan Wu; Xiaofan Su; Lan Yang; Manxiang Li
Journal:  Med Sci Monit       Date:  2015-11-20

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Authors:  Amin Zakeri; Momtchilo Russo
Journal:  Front Immunol       Date:  2018-05-15       Impact factor: 7.561
  2 in total

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