| Literature DB >> 25664014 |
Zhi-Chang Zhang1, Neng-Bin He1, Tao Zhang1.
Abstract
The association between TGF-β1 +869C/T polymorphism and risk of fractures remained controversial. Therefore, we performed this meta-analysis to investigate this association. We searched PubMed, EMBASE, and Wangfang databases for studies before Aug 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association. A total of ten studies were included in this meta-analysis. TGF-β1 +869C/T polymorphism was associated with a significantly increased risk of fracture (OR=1.41; 95% CI, 1.20-1.65; I(2) =0%). In the subgroup analysis according to gender, women was significantly associated with risk of fracture (OR=1.44; 95% CI, 1.20-1.73; I(2) =4%). In the subgroup analysis by race, Asians (OR=1.43; 95% CI, 1.06-1.92; I(2) =0%) and Caucasians (OR=1.44; 95% CI, 1.13-1.85; I(2) =15%) showed increased fracture risk. Our meta-analysis suggested that the TGF-β1 +869C/T polymorphism may be a risk factor for developing fracture.Entities:
Keywords: Fracture; TGF-β1; meta-analysis; polymorphism
Year: 2014 PMID： 25664014 PMCID： PMC4307461
Source DB: PubMed Journal: Int J Clin Exp Med ISSN： 1940-5901