Qing Pang1, Jing-Yao Zhang1, Si-Dong Song1, Kai Qu1, Xin-Sen Xu1, Su-Shun Liu1, Chang Liu1. 1. Qing Pang, Jing-Yao Zhang, Si-Dong Song, Kai Qu, Xin-Sen Xu, Su-Shun Liu, Chang Liu, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
Abstract
AIM: To investigate whether central obesity is associated with nonalcoholic fatty liver disease (NAFLD) formation after adjusting for general obesity. METHODS: The online databases PubMed, EMBASE, and ISI Web of Science were searched for studies estimating the influence of central obesity on NAFLD occurrence published through April 2014. Studies that did not adjust for body mass index (BMI) were excluded. In addition, the independent effect of BMI was also assessed with the included studies. The pooled effect sizes and 95% confidence intervals (CIs) were calculated using random- or fixed-effects models based on the degree of heterogeneity. Furthermore, subgroup analyses, meta-regression, sensitivity analyses, and publication bias were performed. RESULTS: Twenty eligible studies were identified. The summary odds ratio (OR) values per-unit increase in waist circumference (WC) and BMI for NAFLD formation were 1.07 (95%CI: 1.03-1.10, I (2) = 73.9%, n = 11 studies) and 1.25 (95%CI: 1.13-1.38, I (2) = 88.7%, n = 11 studies), respectively. When the indices were expressed as binary variables (with the non-obesity group as reference), the pooled OR in WC, waist-to-hip ratio, and BMI were 2.34 (95%CI: 1.83-3.00, I (2) = 41.8%, n = 7 studies), 4.06 (95%CI: 1.53-10.79, I (2) = 65.7%, n = 3 studies), and 2.85 (95%CI: 1.60-5.08, I (2) = 57.8%, n = 5 studies), respectively. Using the same studies as the latter (n = 5), pooled OR in WC was 3.14 (95%CI: 2.07-4.77), which is greater than that in BMI. CONCLUSION: Central obesity may pose a greater threat to national health than general obesity, although both are independently associated with increased risk of NAFLD.
AIM: To investigate whether central obesity is associated with nonalcoholic fatty liver disease (NAFLD) formation after adjusting for general obesity. METHODS: The online databases PubMed, EMBASE, and ISI Web of Science were searched for studies estimating the influence of central obesity on NAFLD occurrence published through April 2014. Studies that did not adjust for body mass index (BMI) were excluded. In addition, the independent effect of BMI was also assessed with the included studies. The pooled effect sizes and 95% confidence intervals (CIs) were calculated using random- or fixed-effects models based on the degree of heterogeneity. Furthermore, subgroup analyses, meta-regression, sensitivity analyses, and publication bias were performed. RESULTS: Twenty eligible studies were identified. The summary odds ratio (OR) values per-unit increase in waist circumference (WC) and BMI for NAFLD formation were 1.07 (95%CI: 1.03-1.10, I (2) = 73.9%, n = 11 studies) and 1.25 (95%CI: 1.13-1.38, I (2) = 88.7%, n = 11 studies), respectively. When the indices were expressed as binary variables (with the non-obesity group as reference), the pooled OR in WC, waist-to-hip ratio, and BMI were 2.34 (95%CI: 1.83-3.00, I (2) = 41.8%, n = 7 studies), 4.06 (95%CI: 1.53-10.79, I (2) = 65.7%, n = 3 studies), and 2.85 (95%CI: 1.60-5.08, I (2) = 57.8%, n = 5 studies), respectively. Using the same studies as the latter (n = 5), pooled OR in WC was 3.14 (95%CI: 2.07-4.77), which is greater than that in BMI. CONCLUSION:Central obesity may pose a greater threat to national health than general obesity, although both are independently associated with increased risk of NAFLD.
Entities:
Keywords:
Body mass index; Central obesity; General obesity; Nonalcoholic fatty liver disease; Waist circumference
Authors: C Kim; S D Harlow; C A Karvonen-Gutierrez; J F Randolph; M Helmuth; S Kong; B Nan; R Carlos Journal: Diabet Med Date: 2013-06-07 Impact factor: 4.359
Authors: George A Bray; William E Heisel; Ashkan Afshin; Michael D Jensen; William H Dietz; Michael Long; Robert F Kushner; Stephen R Daniels; Thomas A Wadden; Adam G Tsai; Frank B Hu; John M Jakicic; Donna H Ryan; Bruce M Wolfe; Thomas H Inge Journal: Endocr Rev Date: 2018-04-01 Impact factor: 19.871
Authors: Mariana V Machado; Sara Policarpo; J Coutinho; Sofia Carvalhana; Jorge Leitão; Armando Carvalho; Ana P Silva; Francisco Velasco; Isabel Medeiros; Ana Catarina Alves; Mafalda Bourbon; Helena Cortez-Pinto Journal: Obes Surg Date: 2020-02 Impact factor: 4.129
Authors: Kushala W M Abeysekera; James G Orr; Fiona H Gordon; Laura D Howe; Julian Hamilton-Shield; Jon Heron; Matthew Hickman Journal: BMC Gastroenterol Date: 2022-06-30 Impact factor: 2.847
Authors: James L Dorling; Eric Ravussin; Leanne M Redman; Manju Bhapkar; Kim M Huffman; Susan B Racette; Sai K Das; John W Apolzan; William E Kraus; Christoph Höchsmann; Corby K Martin Journal: Eur J Nutr Date: 2020-08-14 Impact factor: 5.614
Authors: Cecilia C Garcia; Bárbara Piotrkowski; Plácida Baz; Daniel Poncino; Javier Benavides; Luis Colombato; María Laura Reyes Toso; Silvina Yantorno; Valeria Descalzi; Gabriel E Gondolesi; Cesar G Fraga; Alejandra C Cherñavsky Journal: Dig Dis Sci Date: 2021-06-22 Impact factor: 3.487