Literature DB >> 25663509

Statin use in cancer patients with brain metastases: a missed communication opportunity at the end of life.

Jacqueline A Mullvain1, Kevin R Kozak, John S Moody, Toby C Campbell.   

Abstract

PURPOSE: Preventive care, referring to medical interventions with anticipated long-term benefits, is often inappropriately continued near the end of life. We examined the use of statin medications in patients with brain metastases receiving whole brain radiation therapy to determine the effect of short life expectancy and regular interaction with oncology providers on statin discontinuation. We propose reasons for the unnecessary continuation of preventive care and suggest that it is a frequently missed communication opportunity to discuss prognosis in a concrete manner.
METHODS: This is a retrospective study examining statin use in patients receiving whole brain radiotherapy for brain metastases. A total of 206 patients at two cancer centers were studied, and information on statin use and clinical characteristics was obtained from review of the medical record.
RESULTS: Of the 206 patients, 53 (26 %) were on a statin at their initial radiation oncology consultation. Of these patients, 13 (25 %) had their statin discontinued by the time of their last follow-up visit, but 40 patients (75 %) were continued on their statin despite their limited life expectancy and low likelihood of benefit.
CONCLUSIONS: The majority of patients who were on statins prior to starting palliative whole brain radiation therapy remained on a statin after completing treatment despite an estimated survival of months and regular visits with an oncologist. This represents a missed opportunity for doctors and patients to discuss the appropriateness of continuing preventive care as part of an important conversation about prognosis.

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Year:  2015        PMID: 25663509     DOI: 10.1007/s00520-015-2624-x

Source DB:  PubMed          Journal:  Support Care Cancer        ISSN: 0941-4355            Impact factor:   3.603


  28 in total

1.  "I wish things were different": expressing wishes in response to loss, futility, and unrealistic hopes.

Authors:  T E Quill; R M Arnold; F Platt
Journal:  Ann Intern Med       Date:  2001-10-02       Impact factor: 25.391

2.  What to tell cancer patients. A study of medical attitudes.

Authors:  D OKEN
Journal:  JAMA       Date:  1961-04-01       Impact factor: 56.272

3.  Discontinuing cardiovascular medications at the end of life: lipid-lowering agents.

Authors:  Annette M Vollrath; Christian Sinclair; James Hallenbeck
Journal:  J Palliat Med       Date:  2005-08       Impact factor: 2.947

4.  Statins in the last six months of life: a recognizable, life-limiting condition does not decrease their use.

Authors:  Maria J Silveira; Anamaria Segnini Kazanis; Matthew P Shevrin
Journal:  J Palliat Med       Date:  2008-06       Impact factor: 2.947

5.  Prognostic disclosure to patients with cancer near the end of life.

Authors:  E B Lamont; N A Christakis
Journal:  Ann Intern Med       Date:  2001-06-19       Impact factor: 25.391

6.  Longitudinal perceptions of prognosis and goals of therapy in patients with metastatic non-small-cell lung cancer: results of a randomized study of early palliative care.

Authors:  Jennifer S Temel; Joseph A Greer; Sonal Admane; Emily R Gallagher; Vicki A Jackson; Thomas J Lynch; Inga T Lennes; Connie M Dahlin; William F Pirl
Journal:  J Clin Oncol       Date:  2011-05-09       Impact factor: 44.544

7.  Patients' expectations about effects of chemotherapy for advanced cancer.

Authors:  Jane C Weeks; Paul J Catalano; Angel Cronin; Matthew D Finkelman; Jennifer W Mack; Nancy L Keating; Deborah Schrag
Journal:  N Engl J Med       Date:  2012-10-25       Impact factor: 91.245

8.  Patient-physician communication during oncology consultations.

Authors:  Hanna Fagerlind; Asa Kettis Lindblad; Ida Bergström; Magdalena Nilsson; Gisela Nauclér; Bengt Glimelius; Lena Ring
Journal:  Psychooncology       Date:  2008-10       Impact factor: 3.894

9.  "Telling bad news": physicians and the disclosure of undesirable information.

Authors:  K M Taylor
Journal:  Sociol Health Illn       Date:  1988-06

10.  'Hitting you over the head': oncologists' disclosure of prognosis to advanced cancer patients.

Authors:  Elisa J Gordon; Christopher K Daugherty
Journal:  Bioethics       Date:  2003-04       Impact factor: 1.898

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  5 in total

1.  Discontinuation of Statins in Veterans Admitted to Nursing Homes near the End of Life.

Authors:  Carolyn T Thorpe; Florentina E Sileanu; Maria K Mor; Xinhua Zhao; Sherrie Aspinall; Mary Ersek; Sydney Springer; Joshua D Niznik; Michelle Vu; Loren J Schleiden; Walid F Gellad; Jacob Hunnicutt; Joshua M Thorpe; Joseph T Hanlon
Journal:  J Am Geriatr Soc       Date:  2020-08-12       Impact factor: 5.562

2.  Older Medicare Beneficiaries Frequently Continue Medications with Limited Benefit Following Hospice Admission.

Authors:  Patrick M Zueger; Holly M Holmes; Gregory S Calip; Dima M Qato; A Simon Pickard; Todd A Lee
Journal:  J Gen Intern Med       Date:  2019-07-25       Impact factor: 6.473

3.  Patterns of statin initiation and continuation in patients with breast or colorectal cancer, towards end-of-life.

Authors:  Amelia Smith; Laura Murphy; Kathleen Bennett; Thomas I Barron
Journal:  Support Care Cancer       Date:  2017-01-18       Impact factor: 3.603

Review 4.  Deprescription in Advanced Cancer Patients.

Authors:  Ferraz Gonçalves
Journal:  Pharmacy (Basel)       Date:  2018-08-21

5.  How many older adults receive drugs of questionable clinical benefit near the end of life? A cohort study.

Authors:  Lucas Morin; Jonas W Wastesson; Marie-Laure Laroche; Johan Fastbom; Kristina Johnell
Journal:  Palliat Med       Date:  2019-06-07       Impact factor: 4.762

  5 in total

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