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Literature DB >> 25662280

Dynamics of adrenal glucocorticoid steroidogenesis in health and disease.

Abstract

The activity of the hypothalamic-pituitary-adrenal (HPA) axis is characterized by an ultradian (pulsatile) pattern of hormone secretion. Pulsatility of glucocorticoids has been found critical for optimal transcriptional, neuroendocrine and behavioral responses. This review will focus on the mechanisms underlying the origin of the glucocorticoid ultradian rhythm. Our recent research shows that the ultradian rhythm of glucocorticoids depends on highly dynamic processes within adrenocortical steroidogenic cells. Furthermore, we have evidence that disruption of these dynamics leads to abnormal glucocorticoid secretion observed in disease and critical illness in both humans and rats.

Entities: Disease Species

Keywords: Adrenal cortex; Glucocorticoids; HPA axis; Inflammation; Steroidogenesis; Ultradian rhythm

Mesh：

Substances：
Glucocorticoids
Steroids

Year: 2015 PMID： 25662280 DOI： 10.1016/j.mce.2015.02.005

Source DB: PubMed Journal: Mol Cell Endocrinol ISSN： 0303-7207 Impact factor: 4.102

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Cited

13 in total

Review 1. A users guide to HPA axis research.

Authors: Robert L Spencer; Terrence Deak
Journal: Physiol Behav Date: 2016-11-18

Review 2. The hunt for a selective 17,20 lyase inhibitor; learning lessons from nature.

Authors: Ian M Bird; David H Abbott
Journal: J Steroid Biochem Mol Biol Date: 2016-05-03 Impact factor: 4.292

3. Vesicular Glutamate Transporter 1 Knockdown in Infralimbic Prefrontal Cortex Augments Neuroendocrine Responses to Chronic Stress in Male Rats.

Authors: Brent Myers; Jessica M McKlveen; Rachel Morano; Yvonne M Ulrich-Lai; Matia B Solomon; Steven P Wilson; James P Herman
Journal: Endocrinology Date: 2017-10-01 Impact factor: 4.736

Review 4. Regulation of Hypothalamo-Pituitary-Adrenocortical Responses to Stressors by the Nucleus of the Solitary Tract/Dorsal Vagal Complex.

Authors: James P Herman
Journal: Cell Mol Neurobiol Date: 2017-09-11 Impact factor: 5.046

10. Alpha- and beta- adrenergic receptors regulate inflammatory responses to acute and chronic sleep fragmentation in mice.

Authors: Nicholas D Wheeler; David C Ensminger; Megan M Rowe; Zachary S Wriedt; Noah T Ashley
Journal: PeerJ Date: 2021-06-24 Impact factor: 2.984

Dynamics of adrenal glucocorticoid steroidogenesis in health and disease.

Review 1. A users guide to HPA axis research.

Review 2. The hunt for a selective 17,20 lyase inhibitor; learning lessons from nature.

3. Vesicular Glutamate Transporter 1 Knockdown in Infralimbic Prefrontal Cortex Augments Neuroendocrine Responses to Chronic Stress in Male Rats.

Review 4. Regulation of Hypothalamo-Pituitary-Adrenocortical Responses to Stressors by the Nucleus of the Solitary Tract/Dorsal Vagal Complex.

5. Altered expression of clock and clock-controlled genes in a hSOD1-linked amyotrophic lateral sclerosis mouse model.

Review 6. Corticosteroids in septic shock: a systematic review and network meta-analysis.

7. Dynamics of ACTH-Mediated Regulation of Gene Transcription in ATC1 and ATC7 Adrenal Zona Fasciculata Cell Lines.

Review 8. The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids.

Review 9. Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility.

10. Alpha- and beta- adrenergic receptors regulate inflammatory responses to acute and chronic sleep fragmentation in mice.