Amanda Roten1, Nathaniel L Baker2, Kevin M Gray3. 1. Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, 125 Doughty Street, Suite 190, MSC 861, Charleston, SC 29425, United States. Electronic address: rotena@musc.edu. 2. Medical University of South Carolina, Department of Public Health Sciences, 135 Cannon Street, MSC 835, Charleston, SC 29425, United States. 3. Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, 125 Doughty Street, Suite 190, MSC 861, Charleston, SC 29425, United States.
Abstract
BACKGROUND: Adolescent marijuana use is associated with neurocognitive impairment, but further work is needed to assess the relationship between treatment-associated abstinence and cognitive performance. METHODS: This secondary analysis, conducted in the context of a marijuana cessation pharmacotherapy trial in adolescents, examined cognitive performance at baseline and at two time points during treatment using the CNS Vital Signs assessment battery. RESULTS: Abstinence from marijuana, relative to continued use, as assessed via urine cannabinoid testing, was associated with significant improvement in composite memory (p<0.001), verbal memory (the most impacted component of composite memory) (p<0.001), and psychomotor performance (p=0.045) scores. CONCLUSIONS: These findings suggest that some domains of cognitive performance improve significantly even in the early stages of treatment-associated abstinence.
RCT Entities:
BACKGROUND: Adolescent marijuana use is associated with neurocognitive impairment, but further work is needed to assess the relationship between treatment-associated abstinence and cognitive performance. METHODS: This secondary analysis, conducted in the context of a marijuana cessation pharmacotherapy trial in adolescents, examined cognitive performance at baseline and at two time points during treatment using the CNS Vital Signs assessment battery. RESULTS: Abstinence from marijuana, relative to continued use, as assessed via urine cannabinoid testing, was associated with significant improvement in composite memory (p<0.001), verbal memory (the most impacted component of composite memory) (p<0.001), and psychomotor performance (p=0.045) scores. CONCLUSIONS: These findings suggest that some domains of cognitive performance improve significantly even in the early stages of treatment-associated abstinence.
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