Literature DB >> 2566186

Behavioural effects of the benzodiazepine receptor partial agonist RO 16-6028 in mice.

C Belzung1, R Misslin, E Vogel.   

Abstract

The imidazo-diazepinone RO 16-6028 is a benzodiazepine receptor partial agonist which exhibits some anti-conflict effects in the two-chambered light/dark test without significantly affecting the behaviour of mice confronted with the staircase test. In addition, this drug slightly reduced locomotion and more markedly rearing in a free exploration procedure. These results indicate that RO 16-6028 appears to produce some anxiolytic and sedative properties like full agonists, but with weaker magnitude. This could be related to the benzodiazepine partial agonistic profile of the compound.

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Year:  1989        PMID： 2566186     DOI： 10.1007/BF00439456

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  25 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1977-09       Impact factor: 11.205

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Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

5.  Interaction of RO 15-4513 and ethanol on the behaviour of mice: antagonistic or additive effects?

Authors:  R Misslin; C Belzung; E Vogel
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

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Journal:  Neuropharmacology       Date:  1987-05       Impact factor: 5.250

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Journal:  J Pharmacol Exp Ther       Date:  1985-12       Impact factor: 4.030

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Authors:  J Simiand; P E Keane; M Morre
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530
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  5 in total

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Journal:  Br J Pharmacol       Date:  1993-10       Impact factor: 8.739

2.  Acute hypernatremia exerts an inhibitory oxytocinergic tone that is associated with anxiolytic mood in male rats.

Authors:  Charles J Frazier; Dipanwita Pati; Helmut Hiller; Dan Nguyen; Lei Wang; Justin A Smith; Kaley MacFadyen; Annette D de Kloet; Eric G Krause
Journal:  Endocrinology       Date:  2013-05-07       Impact factor: 4.736

3.  The use of the rat elevated plus-maze to discriminate between non-selective and BZ-1 (omega 1) selective, benzodiazepine receptor ligands.

Authors:  G Griebel; D J Sanger; G Perrault
Journal:  Psychopharmacology (Berl)       Date:  1996-04       Impact factor: 4.530

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Authors:  J Guldner; L Trachsel; C Kratschmayr; B Rothe; F Holsboer; A Steiger
Journal:  Psychopharmacology (Berl)       Date:  1995-11       Impact factor: 4.530

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Authors:  G Puia; I Ducic; S Vicini; E Costa
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-15       Impact factor: 11.205
  5 in total

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