Literature DB >> 25661385

CC motif chemokine ligand 19 suppressed colorectal cancer in vivo accompanied by an increase in IL-12 and IFN-γ.

Jun Lu1, Junjun Ma1, Wei Cai1, Xiongzhi Wangpu1, Hao Feng2, Jingkun Zhao1, Shaopei Guan1, Yaping Zong3, Aiguo Lu4.   

Abstract

In this study we investigate the role of CC motif chemokine ligand 19 (CCL19) to colorectal cancer (CRC) in vivo. We injected different dose of recombinant mouse CCL19 (rmCCL19) in the tumor site of the model of transplanted tumor. Result shows that rmCCL19 can suppress CRC tumorigenesis and growth in vivo, and it can also prolong overall survival of mice. Quantitative reverse transcription-polymerase chain reaction and enzyme linked immunosorbent assay results showed that the interferon-γ (IFN-γ) and interleukin-12 (IL-12) levels in the tumors and plasma were significantly enhanced after processing with rmCCL19.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Chemokine CCL19; Colorectal cancer; Immunotherapy

Mesh：

Substances：

Year:  2014        PMID： 25661385     DOI： 10.1016/j.biopha.2014.12.032

Source DB:  PubMed          Journal:  Biomed Pharmacother        ISSN： 0753-3322            Impact factor:   6.529


  7 in total

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Journal:  Clin Exp Immunol       Date:  2022-04-04       Impact factor: 4.330

Review 2.  Role of chemokine systems in cancer and inflammatory diseases.

Authors:  Hongyi Li; Min Wu; Xia Zhao
Journal:  MedComm (2020)       Date:  2022-06-08

Review 3.  Therapeutic Lymphoid Organogenesis in the Tumor Microenvironment.

Authors:  Aliyah M Weinstein; Walter J Storkus
Journal:  Adv Cancer Res       Date:  2015-05-05       Impact factor: 6.242

4.  Chemokine Expression Profiles of Human Hepatoma Cell Lines Mediated by Hepatitis B Virus X Protein.

Authors:  Di-Yi Wang; Li-Ping Zou; Xiao-Jia Liu; Hong-Guang Zhu; Rong Zhu
Journal:  Pathol Oncol Res       Date:  2015-11-18       Impact factor: 3.201

5.  CCR4 promotes metastasis via ERK/NF-κB/MMP13 pathway and acts downstream of TNF-α in colorectal cancer.

Authors:  Baochi Ou; Jingkun Zhao; Shaopei Guan; Hao Feng; Xiongzhi Wangpu; Congcong Zhu; Yaping Zong; Junjun Ma; Jing Sun; Xiaohui Shen; Minhua Zheng; Aiguo Lu
Journal:  Oncotarget       Date:  2016-07-26

6.  Modulating Properties of Piroxicam, Meloxicam and Oxicam Analogues against Macrophage-Associated Chemokines in Colorectal Cancer.

Authors:  Paulina Lewandowska; Izabela Szczuka; Iwona Bednarz-Misa; Berenika M Szczęśniak-Sięga; Katarzyna Neubauer; Magdalena Mierzchała-Pasierb; Marek Zawadzki; Wojciech Witkiewicz; Małgorzata Krzystek-Korpacka
Journal:  Molecules       Date:  2021-12-05       Impact factor: 4.411

7.  CCL19 suppresses angiogenesis through promoting miR-206 and inhibiting Met/ERK/Elk-1/HIF-1α/VEGF-A pathway in colorectal cancer.

Authors:  Zhuoqing Xu; Congcong Zhu; Chun Chen; Yaping Zong; Hao Feng; Di Liu; Wenqing Feng; Jingkun Zhao; Aiguo Lu
Journal:  Cell Death Dis       Date:  2018-09-24       Impact factor: 8.469
  7 in total

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