Literature DB >> 25661344

Overexpression of LIMK1 promotes tumor growth and metastasis in gastric cancer.

Tiangeng You1, Wei Gao1, Jun Wei1, Xiaoli Jin1, Zhongxin Zhao1, Congjun Wang1, Yang Li2.   

Abstract

Gastric cancer is the second-leading cause of cancer death in Asia. Despite improvement of therapies, the outcome in patients remains extremely poor because of metastasis. In the present study, we found that LIMK1 is overexpressed in gastric cancer, and its expression level correlate with tumor size, lymph node metastasis and TNM stage. Knockdown of LIMK1 expression could inhibit cell proliferation, migration and invasion in vitro, as well as suppress the activation of FAK/paxillin pathway. Moreover, knockdown of LIMK1 expression retarded tumor growth and peritoneal ametastasis in vivo. This highlights that LIMK1 might be used as a potential target in the treatment of gastric cancer.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  FAK/paxillin; Gastric cancer; LIMK1

Mesh：

Substances：

Year:  2014        PMID： 25661344     DOI： 10.1016/j.biopha.2014.11.011

Source DB:  PubMed          Journal:  Biomed Pharmacother        ISSN： 0753-3322            Impact factor:   6.529


  16 in total

1.  miR-143-3p targeting LIM domain kinase 1 suppresses the progression of triple-negative breast cancer cells.

Authors:  Dengfeng Li; Jiashu Hu; Hongming Song; Hui Xu; Chengyang Wu; Bingkun Zhao; Dan Xie; Tianqi Wu; Junyong Zhao; Lin Fang
Journal:  Am J Transl Res       Date:  2017-05-15       Impact factor: 4.060

2.  Requirement for LIM kinases in acute myeloid leukemia.

Authors:  Patrizia Jensen; Michela Carlet; Richard F Schlenk; Andrea Weber; Jana Kress; Ines Brunner; Mikołaj Słabicki; Gregor Grill; Simon Weisemann; Ya-Yun Cheng; Irmela Jeremias; Claudia Scholl; Stefan Fröhling
Journal:  Leukemia       Date:  2020-06-26       Impact factor: 11.528

3.  Diallyl disulfide suppresses epithelial-mesenchymal transition, invasion and proliferation by downregulation of LIMK1 in gastric cancer.

Authors:  Bo Su; Jian Su; Ying Zeng; Fang Liu; Hong Xia; Yan-Hua Ma; Zhi-Gang Zhou; Shuo Zhang; Bang-Min Yang; You-Hua Wu; Xi Zeng; Xiao-Hong Ai; Hui Ling; Hao Jiang; Qi Su
Journal:  Oncotarget       Date:  2016-03-01

4.  LIM kinase 1 interacts with myosin-9 and alpha-actinin-4 and promotes colorectal cancer progression.

Authors:  Qing Liao; Rui Li; Rui Zhou; Zhihua Pan; Lijun Xu; Yanqing Ding; Liang Zhao
Journal:  Br J Cancer       Date:  2017-06-29       Impact factor: 7.640

5.  Role of miR-647 in human gastric cancer suppression.

Authors:  Wenlong Cao; Weiyuan Wei; Zexu Zhan; Dongyi Xie; Yubo Xie; Qiang Xiao
Journal:  Oncol Rep       Date:  2017-01-17       Impact factor: 3.906

6.  A novel gene expression-based prognostic scoring system to predict survival in gastric cancer.

Authors:  Pin Wang; Yunshan Wang; Bo Hang; Xiaoping Zou; Jian-Hua Mao
Journal:  Oncotarget       Date:  2016-08-23

7.  Downregulation of LIMK1-ADF/cofilin by DADS inhibits the migration and invasion of colon cancer.

Authors:  Jian Su; Yujuan Zhou; Zhibing Pan; Ling Shi; Jing Yang; Aijun Liao; Qianjin Liao; Qi Su
Journal:  Sci Rep       Date:  2017-03-30       Impact factor: 4.379

8.  Regulation of drug resistance and metastasis of gastric cancer cells via the microRNA647-ANK2 axis.

Authors:  Wenlong Cao; Weiyuan Wei; Zexu Zhan; Dongyi Xie; Yubo Xie; Qiang Xiao
Journal:  Int J Mol Med       Date:  2018-01-11       Impact factor: 4.101

9.  MiR-106a directly targets LIMK1 to inhibit proliferation and EMT of oral carcinoma cells.

Authors:  Bingxia Shi; Chao Ma; Guolin Liu; Yanjun Guo
Journal:  Cell Mol Biol Lett       Date:  2019-03-06       Impact factor: 5.787

10.  Upregulation of LIMK1 Is Correlated With Poor Prognosis and Immune Infiltrates in Lung Adenocarcinoma.

Authors:  Guojun Lu; Ying Zhou; Chenxi Zhang; Yu Zhang
Journal:  Front Genet       Date:  2021-06-03       Impact factor: 4.599
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