Literature DB >> 2566114

An Eco RI polymorphic site in the human complement C4 gene distinguishes juvenile rheumatoid arthritis (JRA) susceptibility-bearing haplotypes.

A Arnaiz-Villena1, J L Vicario, J Martinez-Laso, A Corell, J R Regueiro, J Gomez-Reino, J Gomez-Reino.   

Abstract

Susceptibility to acquire Juvenile Rheumatoid Arthritis (JRA) is linked to HLA-DR5 and DRw8 antigens in Caucasoid populations. However, the frequency of HLA-DR5 is too high in the normal Spanish population and JRA cannot thus be found to be associated with this antigen. It has been found a 14.3 kb-C4-Eco RI restriction fragment length polymorphism which correlates significantly with JRA and may be used as a marker for this disorder in Spaniards.

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Year:  1989        PMID： 2566114     DOI： 10.1016/0161-5890(89)90132-6

Source DB:  PubMed          Journal:  Mol Immunol        ISSN： 0161-5890            Impact factor:   4.407


  3 in total

1.  A diallelic RFLP of the CD3-epsilon chain of the clonotypic T-lymphocyte receptor is not associated with certain autoimmune diseases.

Authors:  M Timón; A Arnaiz-Villena; P Pérez-Aciego; P Morales; D Benmamar; J R Regueiro
Journal:  Hum Genet       Date:  1991-02       Impact factor: 4.132

2.  Differential contribution of C4 and HLA-DQ genes to systemic lupus erythematosus susceptibility.

Authors:  D De Juan; J M Martín-Villa; J J Gómez-Reino; J L Vicario; A Corell; J Martínez-Laso; D Benmammar; A Arnaiz-Villena
Journal:  Hum Genet       Date:  1993-07       Impact factor: 4.132

3.  Comparison between HLA-DRB and DQ DNA sequences and classic serological markers as type 1 (insulin-dependent) diabetes mellitus predictive risk markers in the Spanish population.

Authors:  J L Vicario; J Martinez-Laso; A Corell; J M Martin-Villa; P Morales; G Lledo; O G Segurado; D de Juan; A Arnaiz-Villena
Journal:  Diabetologia       Date:  1992-05       Impact factor: 10.122
  3 in total

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