Improving desynchronization of Parkinsonian neuronal network via triplet-structure coordinated reset stimulation.

We investigate how the triplet-structure coordinated reset stimulations (CRS), which acts on the GPe, STN and GPi within the basal ganglia-thalamocortical motor circuit, can destabilize the strong synchronous state and improve the reliability of thalamic relay in the parkinsonian network. It is shown that compared with the permanent (1:0 ON-OFF) CRS or the classic deep brain stimulation paradigm, the periodic m:n ON-OFF CRS (i.e., m ON-cycles stimulation followed by n OFF-cycles stimulation) can significantly desynchronize the neuronal network of Parkinson's disease, and evidently improve the fidelity of thalamic relay. In addition, the CRS-induced desynchronization can be greatly enhanced when the STN subpopulation within the pathologic network is subjected to the synaptic plasticity. Furthermore, the desynchronization and reliability can also be further improved as the closed-loop CRS strategy is introduced. The obtained results can be helpful for us to understand the pathophysiology mechanism of Parkinson's disease, even though the feasibility of CRS still needs to be explored in clinic.