| Literature DB >> 25661068 |
Xiaojun Qiu1, Bin Ji2, Lixiang Yang3, Qingfeng Huang4, Wei Shi4, Zongmei Ding5, Xiaojuan He5, Na Ban5, Shaochen Fan5, Jianguo Zhang6, Ye Tian7.
Abstract
Previous studies have demonstrated that FoxJ2 (forkhead box J2) is a member of Forkhead Box transcription factors and acts as an important prognostic indicator in human breast cancer. Our study aimed to assess the expression and function in human glioma. Western blot analysis and immunohistochemistry were performed in human glioma tissues. Low FoxJ2 expression was observed in 80 samples and its level was correlated with the grade of malignancy. A strongly positive correlation was observed between FoxJ2 and E-cadherin. Overexpression of FoxJ2 increased E-cadherin expression and decreased vimentin expression. The wound healing and transwell assays showed that overexpression of FoxJ2 significantly inhibited their migration in U87 cells. Consistent with this, knockdown of FoxJ2 promoted cellular motility. In a word, FoxJ2 suppressed cell migration and invasion in glioma, which might be a potential novel molecular targeted therapy for surgery and immune treatment.Entities:
Keywords: FoxJ2; Glioma; Migration; Prognosis
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Year: 2015 PMID： 25661068 DOI： 10.1016/j.prp.2015.01.005
Source DB: PubMed Journal: Pathol Res Pract ISSN： 0344-0338 Impact factor: 3.250