Hong Suk Park1, In Wook Choo1, Soowon Seo2, Dongho Hyun1, Sooyoun Lim1, Jae J Kim3, Saet-Byul Hong4, Byung-Hoon Min3, Young Soo Do1, Sung Wook Choo1, Sung Wook Shin1, Kwang Bo Park1, Sung Ki Cho1. 1. Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 2. Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea. 3. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 4. Laboratory Animal Research Center, Samsung Biomedical Research Institute, Seoul, Republic of Korea.
Abstract
BACKGROUND: Migration of stents is one of the most common adverse events in covered stent placement in GI tract obstruction. OBJECTIVE: To compare physical property and migration rates in a canine colon obstruction model among a novel stent and conventional stents. DESIGN: Comparative physical test and animal study. SETTING: Medical device testing laboratory and animal laboratory. SUBJECTS: Mongrel dogs (N=26). INTERVENTIONS: Surgical colon obstruction followed by placement of a novel (n=13) or conventional (n=13) stent. MAIN OUTCOME MEASUREMENTS: Physical properties, migration, and adverse events. RESULTS: The novel stent showed better flexibility, as in a physical test of longitudinal compressibility and axial force, than did conventional stents, and it withstood the fatigue test for 10 days. In terms of radial force and tensile strength, the novel stent showed the same or better results than conventional stents. In a canine colon obstruction model, the migration rate of a novel stent was significantly lower than that of a conventional stent (2/13, 15.4% vs 8/13, 61.5%; P=.008). LIMITATIONS: Animal study of limited size. CONCLUSION: The novel, ring-connected stent is more flexible and more resistant to migration than the conventional stents.
BACKGROUND: Migration of stents is one of the most common adverse events in covered stent placement in GI tract obstruction. OBJECTIVE: To compare physical property and migration rates in a caninecolon obstruction model among a novel stent and conventional stents. DESIGN: Comparative physical test and animal study. SETTING: Medical device testing laboratory and animal laboratory. SUBJECTS: Mongrel dogs (N=26). INTERVENTIONS: Surgical colon obstruction followed by placement of a novel (n=13) or conventional (n=13) stent. MAIN OUTCOME MEASUREMENTS: Physical properties, migration, and adverse events. RESULTS: The novel stent showed better flexibility, as in a physical test of longitudinal compressibility and axial force, than did conventional stents, and it withstood the fatigue test for 10 days. In terms of radial force and tensile strength, the novel stent showed the same or better results than conventional stents. In a caninecolon obstruction model, the migration rate of a novel stent was significantly lower than that of a conventional stent (2/13, 15.4% vs 8/13, 61.5%; P=.008). LIMITATIONS: Animal study of limited size. CONCLUSION: The novel, ring-connected stent is more flexible and more resistant to migration than the conventional stents.
Authors: Jin Ho Hwang; Hong Suk Park; Soowon Seo; In Wook Choo; Young Soo Do; Sung Wook Choo; Sung Wook Shin; Kwang Bo Park; Sung Ki Cho; Dongho Hyun; Sooyoun Lim Journal: Biomed Res Int Date: 2015-08-20 Impact factor: 3.411