Sara J Churchill1, Erica T Wang1,2, Gaisu Bhasin1, Carolyn Alexander1,2, Catherine Bresee1, Marita Pall1, Ricardo Azziz1,3, Ruchi Mathur4, Margareta D Pisarska1,2. 1. Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Cedars-Sinai Medical Center, Los Angeles, CA, USA. 2. Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, David Geffen School of Medicine, University of California, University of California at Los Angeles, Los Angeles, CA, USA. 3. Departments of Obstetrics and Gynecology, and Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA. 4. Department of Medicine, Division of Endocrinology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Abstract
OBJECTIVE: PCOS is associated with obesity and insulin resistance. Efforts have focused on whether an abnormal energy homeostasis contributes to the development of obesity in these patients. There are conflicting results in the literature regarding whether women with PCOS have an altered basal metabolic rate (BMR), thereby leading to difficulties in weight loss. The objective of this study is to compare basal metabolic rate (BMR) in women with PCOS and controls. DESIGN: Cross-sectional study. PATIENTS: One hundred and twenty-eight PCOS patients diagnosed by original NIH consensus criteria and 72 eumenorrheic, non-hirsute controls were recruited from an academic medical centre. MEASUREMENTS: Assessment of BMR using the InBody portable bioelectrical impedance analysis (BIA) device and insulin resistance by HOMA-IR indices. RESULTS: PCOS women were younger than controls. As expected, PCOS subjects had higher body mass index (BMI), serum androgens and estimated insulin resistance. After adjusting for age and BMI, there was no significant difference in BMR between PCOS subjects (adjusted mean 5807 kJ/day, 95% CI 5715-5899) and controls (adjusted mean 5916 kJ/day, 95% CI 5786-6046) (P = 0·193). BMR was also comparable in a secondary analysis comparing PCOS women with and without insulin resistance. CONCLUSIONS: After adjusting for age and BMI, there was no difference in BMR between PCOS women and controls.
OBJECTIVE: PCOS is associated with obesity and insulin resistance. Efforts have focused on whether an abnormal energy homeostasis contributes to the development of obesity in these patients. There are conflicting results in the literature regarding whether women with PCOS have an altered basal metabolic rate (BMR), thereby leading to difficulties in weight loss. The objective of this study is to compare basal metabolic rate (BMR) in women with PCOS and controls. DESIGN: Cross-sectional study. PATIENTS: One hundred and twenty-eight PCOS patients diagnosed by original NIH consensus criteria and 72 eumenorrheic, non-hirsute controls were recruited from an academic medical centre. MEASUREMENTS: Assessment of BMR using the InBody portable bioelectrical impedance analysis (BIA) device and insulin resistance by HOMA-IR indices. RESULTS: PCOS women were younger than controls. As expected, PCOS subjects had higher body mass index (BMI), serum androgens and estimated insulin resistance. After adjusting for age and BMI, there was no significant difference in BMR between PCOS subjects (adjusted mean 5807 kJ/day, 95% CI 5715-5899) and controls (adjusted mean 5916 kJ/day, 95% CI 5786-6046) (P = 0·193). BMR was also comparable in a secondary analysis comparing PCOS women with and without insulin resistance. CONCLUSIONS: After adjusting for age and BMI, there was no difference in BMR between PCOS women and controls.
Authors: Nicholas T Broskey; Monica C Klempel; L Anne Gilmore; Elizabeth F Sutton; Abby D Altazan; Jeffrey H Burton; Eric Ravussin; Leanne M Redman Journal: J Clin Endocrinol Metab Date: 2017-06-01 Impact factor: 5.958
Authors: Emmanuella Doh; Armand Mbanya; Jean Dupont Kemfang-Ngowa; Sama Dohbit; Mycilline Tchana-Sinou; Pascal Foumane; Olivier Trésor Donfack; Anderson S Doh; Jean Claude Mbanya; Eugene Sobngwi Journal: Int J Endocrinol Date: 2016-09-08 Impact factor: 3.257