| Literature DB >> 25660325 |
Shiwen Chen1, Guangfeng Zhao1, Huishuang Miao2, Ruijing Tang2, Yuxian Song2, Yali Hu3, Zhiqun Wang4, Yayi Hou5.
Abstract
Mesenchymal stem cells (MSCs) play an important role in the pathology of preeclampsia (PE). Our previous microarray analysis found that microRNA-494 (miR-494) is highly expressed in decidua-derived MSCs (dMSCs) from PE. We hypothesized that aberrant expression of miR-494 in dMSCs is involved in PE development. In the present study, we found that miR-494 arrests G1/S transition in dMSCs by targeting CDK6 and CCND1. We also found that supernatant from miR-494-overexpressing dMSCs reduces HTR-8/SVneo migration and impairs HUVEC capillary formation by suppressing VEGF. Taken together, we report an unrecognized mechanism of miR-494 affecting dMSC proliferation and function in the pathology of PE.Entities:
Keywords: Angiogenesis; Mesenchymal stem cell; Preeclampsia; Vascular endothelial growth factor; microRNA-494-3p
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Year: 2015 PMID： 25660325 DOI： 10.1016/j.febslet.2015.01.038
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124