Literature DB >> 25659978

Oligonucleotides containing a piperazino-modified 2'-amino-LNA monomer exhibit very high duplex stability and remarkable nuclease resistance.

Chenguang Lou1, Birte Vester, Jesper Wengel.   

Abstract

Incorporation of a piperazino-modified 2'-amino-LNA monomer (PipLNA-T) into oligonucleotides conferred very high affinity and base-pairing selectivity towards complementary DNA and RNA strands. Furthermore, one PipLNA-T modification provided a robust nuclease resistance that safeguarded three neighbouring natural nucleosides from 3'-exonucleolytic degradation. These favourable properties render PipLNA-T a promising oligonucleotide modification for various biological applications.

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Year:  2015        PMID： 25659978     DOI： 10.1039/c5cc00322a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes.

Authors:  Sylvain Geny; Pedro M D Moreno; Tomasz Krzywkowski; Olof Gissberg; Nicolai K Andersen; Abdirisaq J Isse; Amro M El-Madani; Chenguang Lou; Y Vladimir Pabon; Brooke A Anderson; Eman M Zaghloul; Rula Zain; Patrick J Hrdlicka; Per T Jørgensen; Mats Nilsson; Karin E Lundin; Erik B Pedersen; Jesper Wengel; C I Edvard Smith
Journal:  Nucleic Acids Res       Date:  2016-02-08       Impact factor: 16.971

2.  Synthesis and Excellent Duplex Stability of Oligonucleotides Containing 2'-Amino-LNA Functionalized with Galactose Units.

Authors:  Rajesh Kumar; Annika Ries; Jesper Wengel
Journal:  Molecules       Date:  2017-05-21       Impact factor: 4.411

Review 3.  Convertible and Constrained Nucleotides: The 2'-Deoxyribose 5'-C-Functionalization Approach, a French Touch.

Authors:  Crystalle Chardet; Corinne Payrastre; Béatrice Gerland; Jean-Marc Escudier
Journal:  Molecules       Date:  2021-09-30       Impact factor: 4.411

4.  Synthesis of Oligonucleotides Containing 2'-N-alkylaminocarbonyl-2'-amino-LNA (2'-urea-LNA) Moieties Using Post-Synthetic Modification Strategy.

Authors:  Shoko Yamashita; Kodai Nishida; Takashi Osawa; Ayumi Nakanishi; Yuta Ito; Yoshiyuki Hari
Journal:  Molecules       Date:  2020-01-15       Impact factor: 4.411

5.  Polyamine-Oligonucleotide Conjugates: 2'-OMe-Triazole-Linked 1,4,7,10-Tetraazacyclododecane and Intercalating Dyes and Their Effect on the Thermal Stability of DNA Duplexes.

Authors:  Mateusz D Tomczyk; Mariusz Zalewski; Per T Jørgensen; Jesper Wengel; Krzysztof Walczak
Journal:  Pharmaceutics       Date:  2021-12-28       Impact factor: 6.321
  5 in total

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