Jennifer C Sullivan1, Paula Rodriguez-Miguelez2, Margaret A Zimmerman1, Ryan A Harris3. 1. Department of Physiology, Georgia Regents University, Augusta, Georgia; 2. Division of Clinical Translational Science, Georgia Prevention Institute, Department of Pediatrics, Georgia Regents University, Augusta, Georgia; and. 3. Division of Clinical Translational Science, Georgia Prevention Institute, Department of Pediatrics, Georgia Regents University, Augusta, Georgia; and Sport and Exercise Science Research Institute, University of Ulster, Jordanstown, Northern Ireland, United Kingdom ryharris@gru.edu.
Abstract
UNLABELLED: In experimental animal models of hypertension, angiotensin (1-7) [ANG-(1-7)] is higher in females compared with males; however, it is less clear whether the same applies to humans. Therefore, this study sought to compare circulating concentrations of ANG-(1-7) in apparently healthy men and women under normal physiological conditions. With the use of a cross-sectional experimental design, blood was collected in EDTA anticoagulant from 42 volunteers (21 men and 21 women; and age range, 19-48 yr) for analysis of plasma concentrations of ANG-(1-7) and ANG II. Blood pressure was measured and vascular endothelial function was determined (n = 25) using the brachial artery flow-mediated dilation (FMD) test. As a result, women exhibited a higher circulating concentration of ANG-(1-7) (P = 0.04) compared with men, whereas values of ANG II were similar between groups. Baseline arterial diameter, peak diameter, and shear rate were significantly greater (P < 0.02) in men compared with women. No significant differences in FMD, FMD normalized for shear, or time to peak dilation were observed between men and women. In addition, a positive correlation between ANG-(1-7) and FMD (P = 0.04) and negative association between ANG-(1-7) with ANG II (P = 0.01) were only identified in men, whereas a positive relationship between ANG-(1-7) and diastolic blood pressure (P = 0.03) was observed in women. IN CONCLUSION: , women exhibit significantly higher plasma concentrations of ANG-(1-7) compared with men. In addition, this study describes a relationship between ANG-(1-7), vascular function, and diastolic blood pressure that appears to be sex dependent.
UNLABELLED: In experimental animal models of hypertension, angiotensin (1-7) [ANG-(1-7)] is higher in females compared with males; however, it is less clear whether the same applies to humans. Therefore, this study sought to compare circulating concentrations of ANG-(1-7) in apparently healthy men and women under normal physiological conditions. With the use of a cross-sectional experimental design, blood was collected in EDTA anticoagulant from 42 volunteers (21 men and 21 women; and age range, 19-48 yr) for analysis of plasma concentrations of ANG-(1-7) and ANG II. Blood pressure was measured and vascular endothelial function was determined (n = 25) using the brachial artery flow-mediated dilation (FMD) test. As a result, women exhibited a higher circulating concentration of ANG-(1-7) (P = 0.04) compared with men, whereas values of ANG II were similar between groups. Baseline arterial diameter, peak diameter, and shear rate were significantly greater (P < 0.02) in men compared with women. No significant differences in FMD, FMD normalized for shear, or time to peak dilation were observed between men and women. In addition, a positive correlation between ANG-(1-7) and FMD (P = 0.04) and negative association between ANG-(1-7) with ANG II (P = 0.01) were only identified in men, whereas a positive relationship between ANG-(1-7) and diastolic blood pressure (P = 0.03) was observed in women. IN CONCLUSION: , women exhibit significantly higher plasma concentrations of ANG-(1-7) compared with men. In addition, this study describes a relationship between ANG-(1-7), vascular function, and diastolic blood pressure that appears to be sex dependent.
Authors: Judith A Miller; David Z Cherney; John A Duncan; Vesta Lai; Kevin D Burns; Christopher R J Kennedy; Joseph Zimpelmann; Wei Gao; Daniel C Cattran; James W Scholey Journal: J Am Soc Nephrol Date: 2006-08-16 Impact factor: 10.121
Authors: Michele Melo Silva-Antonialli; Rita C A Tostes; Lílian Fernandes; Débora Rejane Fior-Chadi; Eliana Hiromi Akamine; Maria Helena C Carvalho; Zuleica Bruno Fortes; Dorothy Nigro Journal: Cardiovasc Res Date: 2004-06-01 Impact factor: 10.787
Authors: Jennifer C Sullivan; Laura Semprun-Prieto; Erika I Boesen; David M Pollock; Jennifer S Pollock Journal: Am J Physiol Regul Integr Comp Physiol Date: 2007-08-15 Impact factor: 3.619
Authors: David A Calhoun; Daniel Jones; Stephen Textor; David C Goff; Timothy P Murphy; Robert D Toto; Anthony White; William C Cushman; William White; Domenic Sica; Keith Ferdinand; Thomas D Giles; Bonita Falkner; Robert M Carey Journal: Hypertension Date: 2008-04-07 Impact factor: 10.190
Authors: Andrew M South; Patricia A Nixon; Mark C Chappell; Debra I Diz; Gregory B Russell; Elizabeth T Jensen; Hossam A Shaltout; T Michael OʼShea; Lisa K Washburn Journal: J Hypertens Date: 2018-10 Impact factor: 4.844
Authors: Yu Wang; Robin Shoemaker; David Powell; Wen Su; Sean Thatcher; Lisa Cassis Journal: Am J Physiol Heart Circ Physiol Date: 2016-12-16 Impact factor: 4.733
Authors: Y Y Chen; D Liu; P Zhang; J C Zhong; C J Zhang; S L Wu; Y Q Zhang; G Z Liu; M He; L J Jin; H M Yu Journal: J Hum Hypertens Date: 2016-04-28 Impact factor: 3.012
Authors: Matthew J Durand; Natalya S Zinkevich; Michael Riedel; David D Gutterman; Victoria L Nasci; Valerie K Salato; John B Hijjawi; Charles F Reuben; Paula E North; Andreas M Beyer Journal: Arterioscler Thromb Vasc Biol Date: 2016-04-14 Impact factor: 8.311