Hsin-Hung Chiang1, How-Ran Guo2, Hanoch Livneh3, Ming-Chi Lu4, Mei-Ling Yen5, Tzung-Yi Tsai6. 1. Department of Nursing, Dalin Tzuchi Hospital, The Buddhist Tzuchi Medical Foundation, Chiayi, Taiwan; College of Nursing, Chang Gung University of Science and Technology, Chiayi, Taiwan. 2. Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Occupational and Environmental Medicine, National Cheng Kung University Hospital, Tainan, Taiwan. 3. Rehabilitation Counseling Program, Portland State University, USA. 4. Division of Allergy, Immunology and Rheumatology, Dalin Tzuchi Hospital, The Buddhist Tzuchi Medical Foundation, Chiayi, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan. 5. Department of Nursing, Dalin Tzuchi Hospital, The Buddhist Tzuchi Medical Foundation, Chiayi, Taiwan. 6. Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Medical Research, Dalin Tzuchi Hospital, The Buddhist Tzuchi Medical Foundation, Chiayi, Taiwan; Department of Nursing, Tzu Chi College of Technology, Hualien, Taiwan. Electronic address: dm732024@tzuchi.com.tw.
Abstract
OBJECTIVE: Comorbid depressive symptoms are common and undertreated in patients with renal diseases. It remains uncertain whether it is an independent risk factor for poor clinical outcome in patients with chronic kidney disease (CKD). This 3-year study investigated the association of depressive symptoms with long-term outcomes, including initiation of dialysis and all-cause mortality, in a population of CKD patients from Taiwan. METHODS: This prospective cohort study enrolled 262 CKD subjects, none of whom were undergoing dialysis, from a hospital in Taiwan during 2010-2011 and followed them for 3years. At enrollment, all subjects underwent a structured interview with the Taiwan Depression Questionnaire to ascertain the baseline presence of depressive symptoms. Primary end points were initiation of dialysis and all-cause mortality. RESULTS: A total of 21.4% of enrolled patients (56/262) reported the presence of depressive symptoms at baseline. After 3-year follow-up, the risk of composite events (dialysis or death) was significantly higher in CKD patients with depressive symptoms than in those without depressive symptoms (adjusted hazard ratio [AHR]=2.95, 95% confidence interval [CI]: 1.86-4.72). Depressive symptoms at baseline could independently predict the risk of initiation of dialysis (AHR=2.25, 95% CI: 1.27-4.98) or all-cause mortality (AHR=3.08, 95% CI: 1.69-7.06). CONCLUSIONS: Depressive symptoms at baseline were independently associated with increased risk of poor clinical outcomes in CKD patients, which suggested that the prompt provision of appropriate psycho-social care may improve the holistic clinical outcomes for CKD patients.
OBJECTIVE: Comorbid depressive symptoms are common and undertreated in patients with renal diseases. It remains uncertain whether it is an independent risk factor for poor clinical outcome in patients with chronic kidney disease (CKD). This 3-year study investigated the association of depressive symptoms with long-term outcomes, including initiation of dialysis and all-cause mortality, in a population of CKDpatients from Taiwan. METHODS: This prospective cohort study enrolled 262 CKD subjects, none of whom were undergoing dialysis, from a hospital in Taiwan during 2010-2011 and followed them for 3years. At enrollment, all subjects underwent a structured interview with the Taiwan Depression Questionnaire to ascertain the baseline presence of depressive symptoms. Primary end points were initiation of dialysis and all-cause mortality. RESULTS: A total of 21.4% of enrolled patients (56/262) reported the presence of depressive symptoms at baseline. After 3-year follow-up, the risk of composite events (dialysis or death) was significantly higher in CKDpatients with depressive symptoms than in those without depressive symptoms (adjusted hazard ratio [AHR]=2.95, 95% confidence interval [CI]: 1.86-4.72). Depressive symptoms at baseline could independently predict the risk of initiation of dialysis (AHR=2.25, 95% CI: 1.27-4.98) or all-cause mortality (AHR=3.08, 95% CI: 1.69-7.06). CONCLUSIONS:Depressive symptoms at baseline were independently associated with increased risk of poor clinical outcomes in CKDpatients, which suggested that the prompt provision of appropriate psycho-social care may improve the holistic clinical outcomes for CKDpatients.
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